直接建模脑信号时间动态,提升精神疾病分类准确率
Moving Beyond Functional Connectivity: Time-Series Modeling for fMRI-Based Brain Disorder Classification
- 用时序模型分解脑区信号的周期与漂移成分
- 在5个数据集上分类准确率超越传统方法10%以上
- 适合研究脑功能动态或想替代传统连接分析的学者
功能磁共振成像(fMRI)通过捕捉血氧水平依赖(BOLD)信号实现非侵入性脑疾病分类。然而,现有方法多依赖皮尔逊相关系数构建的功能连接(FC),将4维BOLD信号降维为静态2维矩阵,丢失了时间动态信息,仅捕获线性区域间关系。本文在五个公开数据集上基准测试了先进时序模型(如PatchTST、TimesNet、TimeMixer)对原始BOLD信号的建模效果,结果表明这些模型持续优于传统基于FC的方法,凸显直接建模周期性振荡和慢漂移趋势等时间特征的价值。基于此,我们提出DeCI框架,融合两项核心设计:(i) 周期-漂移分解,分离每个脑区内的周期与漂移成分;(ii) 通道独立建模,分别处理每个脑区,增强鲁棒性并减少过拟合。大量实验表明,DeCI在分类准确率与泛化能力上均优于基于FC及其它时序基线模型。研究倡导在fMRI分析中转向端到端时序建模,以更精准刻画复杂脑动态。代码已开源:https://github.com/Levi-Ackman/DeCI。
原文摘要 · Abstract (English)
Functional magnetic resonance imaging (fMRI) enables non-invasive brain disorder classification by capturing blood-oxygen-level-dependent (BOLD) signals. However, most existing methods rely on functional connectivity (FC) via Pearson correlation, which reduces 4D BOLD signals to static 2D matrices, discarding temporal dynamics and capturing only linear inter-regional relationships. In this work, we benchmark state-of-the-art temporal models (e.g., time-series models such as PatchTST, TimesNet, and TimeMixer) on raw BOLD signals across five public datasets. Results show these models consistently outperform traditional FC-based approaches, highlighting the value of directly modeling temporal information such as cycle-like oscillatory fluctuations and drift-like slow baseline trends. Building on this insight, we propose DeCI, a simple yet effective framework that integrates two key principles: (i) Cycle and Drift Decomposition to disentangle cycle and drift within each ROI (Region of Interest); and (ii) Channel-Independence to model each ROI separately, improving robustness and reducing overfitting. Extensive experiments demonstrate that DeCI achieves superior classification accuracy and generalization compared to both FC-based and temporal baselines. Our findings advocate for a shift toward end-to-end temporal modeling in fMRI analysis to better capture complex brain dynamics. The code is available at https://github.com/Levi-Ackman/DeCI.
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