无需训练,仅靠图像相似度即可跨数据集链接脑MRI,揭示隐私漏洞。
Cross-Dataset Linkage of Brain MRI using Image Similarity Measures
- 用标准预处理加直接图像相似度计算实现跨数据集链接
- 在不同扫描仪、时间点、分辨率下达到近乎完美的匹配准确率
- 为神经影像数据共享政策提供实证依据,适合关注隐私安全的研究者
头颅磁共振成像(MRI)数据在严格监管框架下被收集和共享,需移除直接标识符后方可发布。然而,即使经过去颅骨处理,脑组织仍可能保留个体特异性特征,结合辅助信息可实现跨数据集的扫描关联,带来潜在隐私风险。当前监管多依赖定性判断合理性,而以往研究依赖训练或计算复杂的方法。本文表明,仅通过标准预处理流程配合直接图像相似度计算,即可实现对去颅骨的T1加权脑MRI可靠链接。该方法在不同时间点、扫描设备、空间分辨率及采集协议下均取得近似完美匹配准确率,甚至在认知衰退情况下依然有效。实验模拟了大规模神经影像库中跨数据库匹配的真实场景。研究揭示了共享脑MRI数据中此前被低估的重识别风险,为制定前瞻性的数据共享政策提供了实证支持。
原文摘要 · Abstract (English)
Head magnetic resonance imaging (MRI) data are routinely collected and shared for research under strict regulatory frameworks that require the removal of direct identifiers prior to data release. However, even after skull stripping, brain parenchyma may retain participant-specific features that enable linkage of scans acquired from the same individual across datasets, posing a potential privacy risk when combined with auxiliary information. Current regulatory approaches typically assess such risks using qualitative notions of reasonableness. Although prior work has suggested that brain MRI can support subject linkage, existing demonstrations have relied on training-based or computationally intensive methods. Here, we show that reliable linkage of skull-stripped T1-weighted brain MRI is possible using standard preprocessing pipelines followed by direct image similarity computations. Using this simple approach, we achieve near-perfect matching accuracy across datasets acquired at different time points, with varying scanner types, spatial resolutions, and acquisition protocols, and even in the presence of cognitive decline. These experiments simulate realistic scenarios of cross-database matching in large-scale neuroimaging repositories. Our findings highlight a previously underappreciated re-identification risk in shared brain MRI data and provide empirical evidence relevant to the development of informed, forward-looking data-sharing policies in neuroimaging research.
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