arXiv:2602.12883eess.IVcs.CV2026-02中稿 · SPIE Medical Imagi…被引 1

用心脏影像对齐心电图,提升心功能参数提取能力

Dual-Phase Cross-Modal Contrastive Learning for CMR-Guided ECG Representations for Cardiovascular Disease Assessment

  • 通过双相对比学习,将心电图与心动周期两个阶段的3D心脏影像对齐
  • 在英国生物银行数据上,心功能参数提取准确率提升9.2%(达15.6%)
  • 适合做低成本心脏表型分析的研究者或临床应用开发者

心脏磁共振(CMR)可详细评估心脏结构与功能,但普及性受限;心电图(ECG)广泛可用且成本低,却难以反映心脏结构与机械功能。为此,我们提出一种对比学习框架,利用成对的ECG-CMR数据,从心电图中更精准提取临床相关心脏表型。该方法通过双相对比损失,将心电图表示与舒张末期(ED)和收缩末期(ES)的3D CMR体积共同映射至共享隐空间。相比以往仅使用2D CMR或含时间维度的方法,本框架分别建模两个心动周期阶段的3D解剖结构,实现结构与功能属性的灵活解耦。基于英国生物银行超过34,000对ECG-CMR数据,结果表明心功能参数的图像衍生表型提取显著提升(↑9.2%,达15.6%),而临床结局预测改善较小(↑0.7%)。该策略有望实现大规模、低成本的心脏表型提取。代码已公开。

原文摘要 · Abstract (English)

Cardiac magnetic resonance imaging (CMR) offers detailed evaluation of cardiac structure and function, but its limited accessibility restricts use to selected patient populations. In contrast, the electrocardiogram (ECG) is ubiquitous and inexpensive, and provides rich information on cardiac electrical activity and rhythm, yet offers limited insight into underlying cardiac structure and mechanical function. To address this, we introduce a contrastive learning framework that improves the extraction of clinically relevant cardiac phenotypes from ECG by learning from paired ECG-CMR data. Our approach aligns ECG representations with 3D CMR volumes at end-diastole (ED) and end-systole (ES), with a dual-phase contrastive loss to anchor each ECG jointly with both cardiac phases in a shared latent space. Unlike prior methods limited to 2D CMR representations with or without a temporal component, our framework models 3D anatomy at both ED and ES phases as distinct latent representations, enabling flexible disentanglement of structural and functional cardiac properties. Using over 34,000 ECG-CMR pairs from the UK Biobank, we demonstrate improved extraction of image-derived phenotypes from ECG, particularly for functional parameters ($\uparrow$ 9.2\%), while improvements in clinical outcome prediction remained modest ($\uparrow$ 0.7\%). This strategy could enable scalable and cost-effective extraction of image-derived traits from ECG. The code for this research is publicly available.

跨模态学习心电图分析医学影像对比学习

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