用深度学习直接从MRU图像生成小儿肾积水网格,省去繁琐后处理。
KidMesh: Computational Mesh Reconstruction for Pediatric Congenital Hydronephrosis Using Deep Neural Networks
- 基于神经网络端到端重建肾积水网格,无需人工标注网格。
- 每例重建仅需0.4秒,误差小于3.2mm的顶点占比仅3.7%。
- 生成网格可直接用于尿流仿真,助力临床功能评估。
小儿先天性肾积水(CH)是常见泌尿系统疾病,主要由肾盂输尿管连接处梗阻引起。磁共振尿路成像(MRU)利用水的自然对比可清晰显示肾积水结构,包括肾盂和肾盏。现有基于体素的分割方法虽能提取CH区域,但多关注形态特征,如大小、形状和结构。为实现功能评估(如尿动力学模拟),需额外复杂后处理将分割结果转换为网格表示。为此,本文提出一种基于深度神经网络的端到端方法KidMesh,可直接从MRU图像重建CH网格。KidMesh首先从MRU图像提取特征图,通过网格采样生成特征顶点,再据此变形模板网格以生成特定患者的CH网格。同时,我们设计了一种新训练方案,无需依赖难以获取的精确网格标注(因MRU切片稀疏)。实验表明,KidMesh平均仅需0.4秒即可完成网格重建,性能与传统方法相当且无需后处理。重构网格无自交现象,超过3.2mm和6.4mm误差的顶点分别占3.7%和0.2%。经栅格化后,其Dice分数达0.86,与人工勾画的CH掩码一致。此外,这些网格可直接用于肾脏尿液流动模拟,为临床提供重要尿动力学信息。
原文摘要 · Abstract (English)
Pediatric congenital hydronephrosis (CH) is a common urinary tract disorder, primarily caused by obstruction at the renal pelvis-ureter junction. Magnetic resonance urography (MRU) can visualize hydronephrosis, including renal pelvis and calyces, by utilizing the natural contrast provided by water. Existing voxel-based segmentation approaches can extract CH regions from MRU, facilitating disease diagnosis and prognosis. However, these segmentation methods predominantly focus on morphological features, such as size, shape, and structure. To enable functional assessments, such as urodynamic simulations, external complex post-processing steps are required to convert these results into mesh-level representations. To address this limitation, we propose an end-to-end method based on deep neural networks, namely KidMesh, which could automatically reconstruct CH meshes directly from MRU. Generally, KidMesh extracts feature maps from MRU images and converts them into feature vertices through grid sampling. It then deforms a template mesh according to these feature vertices to generate the specific CH meshes of MRU images. Meanwhile, we develop a novel schema to train KidMesh without relying on accurate mesh-level annotations, which are difficult to obtain due to the sparsely sampled MRU slices. Experimental results show that KidMesh could reconstruct CH meshes in an average of 0.4 seconds, and achieve comparable performance to conventional methods without requiring post-processing. The reconstructed meshes exhibited no self-intersections, with only 3.7% and 0.2% of the vertices having error distances exceeding 3.2mm and 6.4mm, respectively. After rasterization, these meshes achieved a Dice score of 0.86 against manually delineated CH masks. Furthermore, these meshes could be used in renal urine flow simulations, providing valuable urodynamic information for clinical practice.
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