arXiv:2602.13666cs.LGcs.AI2026-02中稿 · Symposium on Artif…被引 1

ALMo系统通过交互式调整目标与限制值,提升宫颈癌高剂量率插植放疗的计划效率与质量。

ALMo: Interactive Aim-Limit-Defined, Multi-Objective System for Personalized High-Dose-Rate Brachytherapy Treatment Planning and Visualization for Cervical Cancer

  • 基于目标与限制值直接操作,自动优化放疗参数,减少人工干预。
  • 25例回顾性测试中65%病例剂量学效果优于传统方法,平均规划时间降至17分钟。
  • 适合放疗医生快速生成个性化方案,尤其适用于多目标权衡场景。

在复杂的临床决策中,医生需同时关注多种受目标(理想)和限制(严格)阈值定义的竞争性指标。在宫颈癌的高剂量率(HDR)插植放疗中,治疗计划需严格控制辐射热点,同时平衡肿瘤覆盖与正常器官保护。本文提出ALMo(Aim-Limit-defined Multi-Objective系统),一种交互式决策支持工具,用于推断并实现临床意图。ALMo采用新颖的优化框架,通过自动化参数设置减少手动输入,并灵活控制毒性风险。关键在于,系统允许医生通过直接调节直观的目标与限制值,在剂量学权衡的帕累托前沿上导航。在25例回顾性病例评估中,ALMo生成的计划质量始终不低于甚至超过人工规划,其中65%的病例显示剂量学改善。此外,系统显著提升效率,平均规划时间缩短至约17分钟,远低于传统的30-60分钟。尽管验证于插植放疗,该框架具备通用性,可推广至多准则临床决策的交互优化。

原文摘要 · Abstract (English)

In complex clinical decision-making, clinicians must often track a variety of competing metrics defined by aim (ideal) and limit (strict) thresholds. Sifting through these high-dimensional tradeoffs to infer the optimal patient-specific strategy is cognitively demanding and historically prone to variability. In this paper, we address this challenge within the context of High-Dose-Rate (HDR) brachytherapy for cervical cancer, where planning requires strictly managing radiation hot spots while balancing tumor coverage against organ sparing. We present ALMo (Aim-Limit-defined Multi-Objective system), an interactive decision support system designed to infer and operationalize clinician intent. ALMo employs a novel optimization framework that minimizes manual input through automated parameter setup and enables flexible control over toxicity risks. Crucially, the system allows clinicians to navigate the Pareto surface of dosimetric tradeoffs by directly manipulating intuitive aim and limit values. In a retrospective evaluation of 25 clinical cases, ALMo generated treatment plans that consistently met or exceeded manual planning quality, with 65% of cases demonstrating dosimetric improvements. Furthermore, the system significantly enhanced efficiency, reducing average planning time to approximately 17 minutes, compared to the conventional 30-60 minutes. While validated in brachytherapy, ALMo demonstrates a generalized framework for streamlining interaction in multi-criteria clinical decision-making.

放疗计划多目标优化交互设计

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