无需标记物，用双目视觉实现手术机器人末端6自由度精准定位。

Flexible endoscopic continuum manipulators offer high dexterity and access to complex anatomy, but nonlinear hysteresis limits feedforward control accuracy. Closed-loop control can compensate for these errors but requires accurate six-degree-of-freedom (6D) end-effector pose feedback. We present MarUco, a markerless 6D pose estimation framework for closed-loop control using only stereo vision during operation. A photorealistic pseudo-rigid-body simulation pipeline generates large-scale annotated training data without manual labeling. A multifeature fusion network integrates masks, keypoints, heatmaps, and bounding boxes from both stereo views to estimate an initial pose, followed by a learned single-pass render-and-compare module that refines the pose without iterative optimization. Kinematics-free hand-eye calibration estimates camera-to-robot-base extrinsics, and self-supervised adaptation uses unlabeled real stereo pairs to mitigate sim-to-real pose error. Across 1,000 real samples, MarUco achieves translation and rotation errors of 0.78 $\pm$ 0.50 mm and 3.07 $\pm$ 1.25°, respectively, with a total processing time of 52.4 ms per stereo pair. In closed-loop experiments over eight reference paths, MarUco achieves a mean terminal translation error of 1.8 mm, an 88% reduction relative to uncompensated open-loop control. To the best of our knowledge, this is the first markerless position-based visual servoing framework for continuum manipulators.