用脑电非侵入式实时解码老鼠自主行走速度,准确率达0.88相关性。
Online decoding of rat self-paced locomotion speed from EEG using recurrent neural networks
- 用32通道皮层脑电+循环神经网络,实时解码自主行走速度。
- 相关性达0.88(R²=0.78),主要依赖视觉皮层和低频振荡。
- 神经信号可预测过去和未来1秒内的运动动态,适合神经机制研究。
目标:精准解码运动神经活动对康复、假肢控制及动作神经机制理解具有重要意义。现有研究多在机械跑步机上解码运动参数,但针对自主选择速度的自然运动场景,非侵入式解码仍罕见且精度有限。本文旨在通过鼠类头固定状态下自选速度行走时的全皮层脑电(EEG)记录,实现非侵入、连续的运动速度解码。方法:提出一种异步脑机接口,处理32电极颅表脑电(0.01–45 Hz),利用超过133小时数据集,训练循环神经网络将持续脑电活动映射至跑步机速度。结果:解码相关性达0.88(R² = 0.78),主要由视觉皮层电极和<8 Hz低频振荡驱动;单次预训练即可用于同一动物其他会话的解码,表明跨会话一致性,但无法跨动物迁移。此外,皮层状态不仅反映当前速度,还携带前/后1000毫秒的运动动态信息。意义:首次证明非侵入式全皮层脑电可高精度连续解码自主运动速度,为高性能非侵入式脑机接口提供框架,并深化对动作动态分布式神经编码的理解。
原文摘要 · Abstract (English)
$\textit{Objective.}$ Accurate neural decoding of locomotion holds promise for advancing rehabilitation, prosthetic control, and understanding neural correlates of action. Recent studies have demonstrated decoding of locomotion kinematics across species on motorized treadmills. However, efforts to decode locomotion speed in more natural contexts$-$where pace is self-selected rather than externally imposed$-$are scarce, generally achieve only modest accuracy, and require intracranial implants. Here, we aim to decode self-paced locomotion speed non-invasively and continuously using cortex-wide EEG recordings from rats. $\textit{Approach.}$ We introduce an asynchronous brain$-$computer interface (BCI) that processes a stream of 32-electrode skull-surface EEG (0.01$-$45 Hz) to decode instantaneous speed from a non-motorized treadmill during self-paced locomotion in head-fixed rats. Using recurrent neural networks and a dataset of over 133 h of recordings, we trained decoders to map ongoing EEG activity to treadmill speed. $\textit{Main results.}$ Our decoding achieves a correlation of 0.88 ($R^2$ = 0.78) for speed, primarily driven by visual cortex electrodes and low-frequency ($< 8$ Hz) oscillations. Moreover, pre-training on a single session permitted decoding on other sessions from the same rat, suggesting uniform neural signatures that generalize across sessions but fail to transfer across animals. Finally, we found that cortical states not only carry information about current speed, but also about future and past dynamics, extending up to 1000 ms. $\textit{Significance.}$ These findings demonstrate that self-paced locomotion speed can be decoded accurately and continuously from non-invasive, cortex-wide EEG. Our approach provides a framework for developing high-performing, non-invasive BCI systems and contributes to understanding distributed neural representations of action dynamics.
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