用患者心电图和影像生成4D心脏动态影像,提升临床分析可用性。
Chain of Flow: ECG-Conditioned 4D Cardiac Cine Generation from Patient-Specific Anatomical Anchor
- 结合患者心电图与影像,生成个性化4D心脏电影。
- 在英国生物银行数据集上实现高质量结构与功能表现。
- 适用于缺省相位或跨时间点分析,适合心脏病研究者使用。
心脏电影磁共振成像(MRI)对心脏功能评估至关重要,但当前完整的心脏电影序列未必总能及时获取。我们提出链式流(Chain of Flow, COF)框架,利用患者特异性MRI与当前心电图(ECG)生成个体化4D心脏电影。在英国生物银行数据集上,COF在共享同次访问可评估基准中表现出优异的图像保真度与下游功能性能。多切片、多分辨率分析显示短轴堆叠与不同采集分辨率下结构生成稳定。对重采样输入心脏相位的受控鲁棒性分析进一步验证了在目标相位不可见时,使用当前患者影像加心电图作为同次访问代理的有效性。跨时间点路径提供探索性序列证据,尤其在面向当前关注区域的读取中收益显著。疾病类别功能审计及病例级容积轨迹证据审查进一步揭示了该方法在解剖感知的下游心脏分析中保持稳定的边界。代码已公开于 https://anonymous.4open.science/r/COF-paper-release-C88B。
原文摘要 · Abstract (English)
Cardiac cine magnetic resonance imaging (MRI) is central to functional cardiac assessment, yet a full current cine sequence may not always be directly available at the point of analysis. We introduce Chain of Flow (COF), an electrocardiography (ECG)-conditioned framework that combines patient-specific MRI and current ECG for subject-specific 4D cardiac cine generation. On the UK Biobank dataset, COF achieves strong image-level fidelity and downstream function-oriented performance on a shared same-visit evaluable benchmark. Multi-slice and multi-resolution analyses indicate stable structural generation quality across the short-axis stack and heterogeneous acquisition resolutions. Controlled phase-robustness analyses across resampled input MRI phases further provide same-visit proxy support for patient-specific MRI plus current ECG when a target MRI phase is not directly observed. A cross-visit route provides exploratory serial evidence, with the clearest gains in current-facing region-of-interest readout. Disease-category functional audits, case-level volume-trajectory evidence review further delineate where the current patient-specific MRI plus ECG formulation remains stable for anatomy-aware downstream cardiac analysis. Code is available at https://anonymous.4open.science/r/COF-paper-release-C88B.
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