用历史病例指导的智能分诊系统,降低乳腺超声误诊和活检率。
Experience-Guided Self-Adaptive Cascaded Agents for Breast Cancer Screening and Diagnosis with Reduced Biopsy Referrals
- 分两阶段决策:先筛除低风险病例,高风险再进专业诊断
- 减少活检率37.08%,诊断升级率从84.95%降至58.72%
- 基于过往案例动态调整判断标准,无需重新训练模型
我们提出一种经验引导的级联多智能体框架BUSD-Agent,用于乳腺超声筛查与诊断,旨在降低诊断升级和不必要的活检推荐。该框架将筛查与诊断建模为两级选择性决策过程。一个轻量级‘筛查诊所’代理,仅使用分类模型作为工具,当恶性风险和不确定性较低时,主动筛选出良性及正常病例,避免进一步升级。高风险病例则被升至‘诊断诊所’代理,该代理整合更丰富的感知与放射学描述工具,做出二次活检推荐决策。为提升性能,系统将病理确诊结果、图像嵌入、模型预测及历史代理行为存入记忆库,形成结构化决策轨迹。对于新病例,BUSD-Agent基于图像、模型响应与置信度相似性检索相似历史案例,以条件化当前决策策略。这实现了无需参数更新的上下文适应,动态调整模型信任度与升级阈值。在10个乳腺超声数据集上的评估显示,相比无轨迹条件化的相同架构,该方法将诊断升级率从84.95%降至58.72%,总体活检推荐率从59.50%降至37.08%,同时平均筛查特异性提升68.48%,诊断特异性提升6.33%。
原文摘要 · Abstract (English)
We propose an experience-guided cascaded multi-agent framework for Breast Ultrasound Screening and Diagnosis, called BUSD-Agent, that aims to reduce diagnostic escalation and unnecessary biopsy referrals. Our framework models screening and diagnosis as a two-stage, selective decision-making process. A lightweight `screening clinic' agent, restricted to classification models as tools, selectively filters out benign and normal cases from further diagnostic escalation when malignancy risk and uncertainty are estimated as low. Cases that have higher risks are escalated to the `diagnostic clinic' agent, which integrates richer perception and radiological description tools to make a secondary decision on biopsy referral. To improve agent performance, past records of pathology-confirmed outcomes along with image embeddings, model predictions, and historical agent actions are stored in a memory bank as structured decision trajectories. For each new case, BUSD-Agent retrieves similar past cases based on image, model response and confidence similarity to condition the agent's current decision policy. This enables retrieval-conditioned in-context adaptation that dynamically adjusts model trust and escalation thresholds from prior experiences without parameter updates. Evaluation across 10 breast ultrasound datasets shows that the proposed experience-guided workflow reduces diagnostic escalation in BUSD-Agent from 84.95% to 58.72% and overall biopsy referrals from 59.50% to 37.08%, compared to the same architecture without trajectory conditioning, while improving average screening specificity by 68.48% and diagnostic specificity by 6.33%.
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