arXiv:2603.00223cs.CVquant-ph2026-03

用量子启发方法做癌症分类,效果优于传统模型。

Pretty Good Measurement for Radiomics: A Quantum-Inspired Multi-Class Classifier for Lung Cancer Subtyping and Prostate Cancer Risk Stratification

  • 基于量子态辨识思想设计多类别分类器,避免两两比较
  • 肺癌分型准确率超传统方法,四类任务仍保持竞争力
  • 适合医学影像分类,尤其对重叠类别的区分有优势

本文研究一种基于漂亮好测量(PGM)的量子启发监督多分类方法,将每类映射为一个混合态,通过单一正算子值测量(POVM)实现真正多类分类,无需拆解为成对或一对多任务。分类被重新建模为不同类别密度算符之间的判别问题,性能由编码映射诱导的几何结构及类别间重叠关系决定。在两个放射组学案例中评估:非小细胞肺癌(NSCLC)组织病理亚型分类与前列腺癌(PCa)风险分级。实验采用与已有研究一致的协议,可直接对比经典基线。结果表明,该方法始终具有竞争力,在NSCLC二分类和三分类任务中表现优异;四分类任务中虽因类别重叠更难,仍保持良好性能。在PCa任务中,其表现接近最强集成基线,并在不同特征选择下展现出临床相关的敏感性-特异性权衡。

原文摘要 · Abstract (English)

We investigate a quantum-inspired approach to supervised multi-class classification based on the Pretty Good Measurement (PGM), viewed as an operator-valued decision rule derived from quantum state discrimination. The method associates each class with an encoded mixed state and performs classification through a single POVM construction, thus providing a genuinely multi-class strategy without reduction to pairwise or one-vs-rest schemes. In this perspective, classification is reformulated as the discrimination of a finite ensemble of class-dependent density operators, with performance governed by the geometry induced by the encoding map and by the overlap structure among classes. To assess the practical scope of this framework, we apply the PGM-based classifier to two biomedical radiomics case studies: histopathological subtyping of non-small-cell lung carcinoma (NSCLC) and prostate cancer (PCa) risk stratification. The evaluation is conducted under protocols aligned with previously reported radiomics studies, enabling direct comparison with established classical baselines. The results show that the PGM-based classifier is consistently competitive and, in several settings, improves upon standard methods. In particular, the method performs especially well in the NSCLC binary and three-class tasks, while remaining competitive in the four-class case, where increased class overlap yields a more demanding discrimination geometry. In the PCa study, the PGM classifier remains close to the strongest ensemble baseline and exhibits clinically relevant sensitivity--specificity trade-offs across feature-selection scenarios.

医学影像癌症分型量子启发多分类

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