arXiv:2603.00460cs.AI2026-03ACL被引 2

用知识图谱和相似病例检索增强医学大模型,提升临床决策可信度。

MED-COPILOT: A Medical Assistant Powered by GraphRAG and Similar Patient Case Retrieval

论文配图:MED-COPILOT: A Medical Assistant Powered by GraphRAG and Similar Patient Case Retrieval
图 1 · 摘自论文原文
  • 构建指南知识图谱+患者病例数据库,融合结构化与非结构化医学信息
  • 在病历补全与问答任务中,生成准确率和推理正确率均优于传统RAG
  • 支持证据可追溯、相似性可视化,适合医生和医学生临床辅助使用

临床决策需要整合患者病史、临床指南及相似病例轨迹等异构证据。尽管大语言模型具备强大推理能力,但易产生幻觉且难以处理长篇结构化医学文档。我们提出MED-COPILOT,一个面向临床医生和医学生的交互式决策支持系统,结合指南驱动的GraphRAG检索与混合语义-关键词相似患者检索,实现透明且基于证据的临床推理。系统从WHO与NICE指南构建结构化知识图谱,采用社区级摘要提升检索效率,并建立包含36,000例患者的相似病例库,数据源自SOAP标准化的MIMIC-IV病历与Synthea生成记录。在病历补全与医学问答任务上评估,结果表明其持续优于参数化LLM基线与标准RAG,显著提升生成保真度与临床推理准确性。完整系统已开源至HuggingFace空间,支持用户查看检索证据、可视化词级相似贡献并开展引导式分析。结果证明了将结构化指南知识与患者级类比证据有效融合于临床大模型的可行性与实用性。

原文摘要 · Abstract (English)

Clinical decision-making requires synthesizing heterogeneous evidence, including patient histories, clinical guidelines, and trajectories of comparable cases. While large language models (LLMs) offer strong reasoning capabilities, they remain prone to hallucinations and struggle to integrate long, structured medical documents. We present MED-COPILOT, an interactive clinical decision-support system designed for clinicians and medical trainees, which combines guideline-grounded GraphRAG retrieval with hybrid semantic-keyword similar-patient retrieval to support transparent and evidence-aware clinical reasoning. The system builds a structured knowledge graph from WHO and NICE guidelines, applies community-level summarization for efficient retrieval, and maintains a 36,000-case similar-patient database derived from SOAP-normalized MIMIC-IV notes and Synthea-generated records. We evaluate our framework on clinical note completion and medical question answering, and demonstrate that it consistently outperforms parametric LLM baselines and standard RAG, improving both generation fidelity and clinical reasoning accuracy. The full system is available at https://huggingface.co/spaces/Cryo3978/Med_GraphRAG , enabling users to inspect retrieved evidence, visualize token-level similarity contributions, and conduct guided follow-up analysis. Our results demonstrate a practical and interpretable approach to integrating structured guideline knowledge with patient-level analogical evidence for clinical LLMs.

医学AI知识图谱RAG

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