无需配对数据,用扩散模型修复低场核磁图像的对比度失真。
Zero-shot Low-Field MRI Enhancement via Diffusion-Based Adaptive Contrast Transport
- 利用可微分最优传输建模低/高场间强度分布差异,动态学习对比度映射。
- 在真实临床数据上重建出结构更清晰、组织对比度更准确的图像。
- 适合医疗影像超分辨率与无监督医学图像恢复研究者参考。
低场(LF)磁共振成像虽能降低设备门槛,但受限于信噪比低和因场强依赖弛豫动力学导致的显著组织对比度失真。从低场数据重建高场(HF)质量图像是一个无监督的逆问题,受制于缺乏成对训练数据及未知的非线性对比度变换算子。现有零样本方法假设简化线性退化,常无法恢复真实组织对比度。本文提出DACT(基于扩散的自适应对比度传输)框架,无需配对监督即可恢复高场图像质量。DACT结合预训练的高场扩散先验以保证解剖结构保真度,并引入物理启发的自适应前向模型。特别地,设计了一个可微分的Sinkhorn最优传输模块,在反向扩散过程中显式建模并校正低场与高场域间的强度分布偏移,使框架能动态学习难以求解的对比度映射,同时保持拓扑一致性。在模拟与真实临床低场数据集上的大量实验表明,DACT达到当前最优性能,重建图像具有更优的结构细节与正确的组织对比度。
原文摘要 · Abstract (English)
Low-field (LF) magnetic resonance imaging (MRI) democratizes access to diagnostic imaging but is fundamentally limited by low signal-to-noise ratio and significant tissue contrast distortion due to field-dependent relaxation dynamics. Reconstructing high-field (HF) quality images from LF data is a blind inverse problem, severely challenged by the scarcity of paired training data and the unknown, non-linear contrast transformation operator. Existing zero-shot methods, which assume simplified linear degradation, often fail to recover authentic tissue contrast. In this paper, we propose DACT(Diffusion-Based Adaptive Contrast Transport), a novel zero-shot framework that restores HF-quality images without paired supervision. DACT synergizes a pre-trained HF diffusion prior to ensure anatomical fidelity with a physically-informed adaptive forward model. Specifically, we introduce a differentiable Sinkhorn optimal transport module that explicitly models and corrects the intensity distribution shift between LF and HF domains during the reverse diffusion process. This allows the framework to dynamically learn the intractable contrast mapping while preserving topological consistency. Extensive experiments on simulated and real clinical LF datasets demonstrate that DACT achieves state-of-the-art performance, yielding reconstructions with superior structural detail and correct tissue contrast.
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