arXiv:2603.02079cs.CV2026-03被引 2

让AI像医生一样多倍率动态看切片,提升病理诊断准确率。

MMNavAgent: Multi-Magnification WSI Navigation Agent for Clinically Consistent Whole-Slide Analysis

  • 设计跨倍率导航工具与自适应选倍工具,模拟医生看片流程。
  • 在公开数据集上实现AUC提升1.45%,平衡准确率提升2.93%。
  • 适合需要高精度病理分析的医学AI研究者使用。

现有AI导航方法虽能提升全切片图像(WSI)诊断效率,但通常仅在单一固定倍率下工作或依赖预设倍率遍历。临床实践中,病理科医生会根据需要在多个倍率间切换,动态整合全局与细胞级信息。现有方法难以建模跨倍率交互与自适应选择机制。为此,我们提出临床一致的多倍率WSI导航代理MMNavAgent,显式建模多倍率交互与自适应倍率选择。具体提出跨倍率导航工具(CMT),通过融合相邻倍率上下文增强路径上的判别性表征;并引入倍率选择工具(MST),在代理框架内基于记忆推理实现交互式、自适应倍率选择,模拟医生的逐步决策过程。在公开数据集上的大量实验表明,相比非代理基线,本方法在AUC上提升1.45%,在平衡准确率(BACC)上提升2.93%。代码将在论文接受后公开。

原文摘要 · Abstract (English)

Recent AI navigation approaches aim to improve Whole-Slide Image (WSI) diagnosis by modeling spatial exploration and selecting diagnostically relevant regions, yet most operate at a single fixed magnification or rely on predefined magnification traversal. In clinical practice, pathologists examine slides across multiple magnifications and selectively inspect only necessary scales, dynamically integrating global and cellular evidence in a sequential manner. This mismatch prevents existing methods from modeling cross-magnification interactions and adaptive magnification selection inherent to real diagnostic workflows. To these, we propose a clinically consistent Multi-Magnification WSI Navigation Agent (MMNavAgent) that explicitly models multi magnification interaction and adaptive magnification selection. Specifically, we introduce a Cross-Magnification navigation Tool (CMT) that aggregates contextual information from adjacent magnifications to enhance discriminative representations along the navigation path. We further introduce a Magnification Selection Tool (MST) that leverages memory-driven reasoning within the agent framework to enable interactive and adaptive magnification selection, mimicking the sequential decision process of pathologists. Extensive experiments on a public dataset demonstrate improved diagnostic performance, with 1.45% gain of AUC and 2.93% gain of BACC over a non-agent baseline. Code will be public upon acceptance.

病理分析多倍率导航代理医学AI

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