自动提取声门波形,精准区分健康与病变状态。
A Detection-Gated Pipeline for Robust Glottal Area Waveform Extraction and Clinical Pathology Assessment
- 用YOLO定位+U-Net分割,加门控减少误检。
- 跨数据集测试DSC达0.745,实时处理35帧/秒。
- 临床验证可区分健康与病变,适合医生快速评估。
我们提出一种全自动、两阶段模块化声门区域分割框架,用于高速视频内窥镜(HSV),兼顾准确性、泛化性和实时播放。检测门控流水线结合YOLOv8n声门定位器与U-Net分割器;定位器生成紧凑裁剪区域以保持一致视野,并通过门控机制减少声门闭合时的伪阳性分割。模型在GIRAFE(N=600)和BAGLS(N=55,750)数据集上训练。通过在未微调情况下将GIRAFE训练模型部署于BAGLS测试集,评估跨数据集可迁移性,系统在该条件下取得0.745的骰子相似系数(为域内上限的87%)。在同分布测试集上,系统分别达到0.81(GIRAFE)和0.856(BAGLS)的骰子相似系数,优于或媲美现有最优方法。对40名受试者的探索性临床研究显示,声门面积变异系数(CV)能有效区分健康与病理功能(p=0.006)。系统在消费级硬件上实现约35帧/秒的处理速度,支持交互式临床回放。该设计可统一提取不同采集条件下的喉部运动学指标。代码、权重与软件已公开于https://github.com/hari-krishnan/openglottal。
原文摘要 · Abstract (English)
We present a fully automated, two-stage modular glottal area segmentation framework for high-speed videoendoscopy (HSV) designed for accuracy, generalizability, and real-time playback. Our detection-gated pipeline combines a YOLOv8n glottis localizer with a U-Net segmenter; the localizer defines a tight crop to ensure a consistent field of view and gates the output to reduce spurious segmentations during glottal closure. The models were trained on the GIRAFE (N=600) and BAGLS (N=55,750) datasets. Cross-dataset portability was evaluated by benchmarking GIRAFE-trained models on the BAGLS test set without fine-tuning. In these evaluations, the pipeline achieved a Dice Similarity Coefficient (DSC) of 0.745 (87% of the in-domain ceiling). On in-distribution test sets, the system achieved DSCs of 0.81 (GIRAFE) and 0.856 (BAGLS), outperforming or competing with state-of-the-art methods. An exploratory clinical study of 40 subjects demonstrated that the glottal area Coefficient of Variation (CV distinguished healthy from pathological function (p=0.006). The system processes ~35 frames per second on commodity hardware, enabling interactive clinical review. This design supports uniform extraction of laryngeal kinematic measures across varying acquisition settings. Code, weights, and software are available at https://github.com/hari-krishnan/openglottal.
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