用功能分区提升自闭症分类准确率,达到95%
Beyond Anatomy: Explainable ASD Classification from rs-fMRI via Functional Parcellation and Graph Attention Networks
- 用功能分区代替传统解剖分区构建脑图
- 分类准确率达95%,优于现有方法
- 模型关注的脑区与自闭症病理一致
基于静息态fMRI的自闭症谱系障碍(ASD)分类通常依赖解剖脑分区,但其固定边界难以捕捉自闭症特有的连接模式。本研究在ABIDE I数据集上对比解剖分区(AAL,116个区域)与功能分区(MSDL,39个区域)策略,采用FSL预处理流程应对400名均衡受试者中的多中心异质性,按站点划分70/15/15训练验证测试集以避免数据泄露。训练阶段通过高斯噪声增强样本数从280扩至1680。三阶段流程:先以AAL为基础的GCN达73.3%准确率(AUC=0.74),再优化为基于MSDL的GCN达84.0%(AUC=0.84),最终采用图注意力网络集成模型实现95.0%准确率(AUC=0.98),超越所有近期基于GNN的基准。仅更换分区方式即带来10.7个百分点提升,表明功能分区是关键建模决策。基于梯度的显著性分析与GNNExplainer结果一致指向后扣带皮层和楔前叶,为默认模式网络核心枢纽,验证模型决策反映真实神经病理而非采集伪影。所有代码与数据将在论文接受后公开。
原文摘要 · Abstract (English)
Anatomical brain parcellations dominate rs-fMRI-based Autism Spectrum Disorder (ASD) classification, yet their rigid boundaries may fail to capture the idiosyncratic connectivity patterns that characterise ASD. We present a graph-based deep learning framework comparing anatomical (AAL, 116 ROIs) and functionally-derived (MSDL, 39 ROIs) parcellation strategies on the ABIDE I dataset. Our FSL preprocessing pipeline handles multi-site heterogeneity across 400 balanced subjects, with site-stratified 70/15/15 splits to prevent data leakage. Gaussian noise augmentation within training folds expands samples from 280 to 1,680. A three phase pipeline progresses from a baseline GCN with AAL (73.3% accuracy, AUC=0.74), to an optimised GCN with MSDL (84.0%, AUC=0.84), to a Graph Attention Network ensemble achieving 95.0% accuracy (AUC=0.98), outperforming all recent GNN-based benchmarks on ABIDE I. The 10.7-point gain from atlas substitution alone demonstrates that functional parcellation is the most impactful modelling decision. Gradient-based saliency and GNNExplainer analyses converge on the Posterior Cingulate Cortex and Precuneus as core Default Mode Network hubs, validating that model decisions reflect ASD neuropathology rather than acquisition artefacts. All code and datasets will be publicly released upon acceptance.
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