用术前MRI和AI自动预测结直肠肝转移术后生存期,帮医生判断是否手术合适。
An Automated Radiomics Framework for Postoperative Survival Prediction in Colorectal Liver Metastases using Preoperative MRI
- 用提示引导的3D分割模型自动勾画肝脏、肿瘤和脾脏,减少人工标注
- 基于影像特征的生存预测模型达到C-index 0.69,优于传统方法
- 适合临床决策支持,尤其为术前评估提供客观依据
结直肠肝转移(CRLM)虽可通过肝切除治愈,但患者预后差异大。本研究提出一种基于AI的自动化框架,利用术前增强MRI预测术后生存率。回顾分析2013至2020年间接受钆塞酸增强MRI的227例患者。框架包含解剖感知分割与影像组学分析两部分:分割部分采用可提示的基础模型生成伪标签,提出SAMONAI算法实现3D点云分割;随后将分割结果输入影像组学流程,使用基于自编码器的多实例神经网络SurvAMINN进行生存预测,该模型在右删失数据上联合学习降维与生存建模,重点关注高风险病灶。分割平均Dice系数达0.96(肝)、0.93(脾),肿瘤分割为0.78,检测F1为0.79。影像组学预测模型获得C-index 0.69,优于传统指标。结果表明,整合分割与影像组学可实现准确、全自动的CRLM预后评估。
原文摘要 · Abstract (English)
While colorectal liver metastasis (CRLM) is potentially curable via hepatectomy, patient outcomes remain highly heterogeneous. Postoperative survival prediction is necessary to avoid non-beneficial surgeries and guide personalized therapy. In this study, we present an automated AI-based framework for postoperative CRLM survival prediction using pre- and post-contrast MRI. We performed a retrospective study of 227 CRLM patients who had gadoxetate-enhanced MRI prior to curative-intent hepatectomy between 2013 and 2020. We developed a survival prediction framework comprising an anatomy-aware segmentation pipeline followed by a radiomics pipeline. The segmentation pipeline learns liver, CRLMs, and spleen segmentation from partially-annotated data, leveraging promptable foundation models to generate pseudo-labels. To support this pipeline, we propose SAMONAI, a prompt propagation algorithm that extends Segment Anything Model to 3D point-based segmentation. Predicted pre- and post-contrast segmentations are then fed into our radiomics pipeline, which extracts per-tumor features and predicts survival using SurvAMINN, an autoencoder-based multiple instance neural network for time-to-event survival prediction. SurvAMINN jointly learns dimensionality reduction and survival prediction from right-censored data, emphasizing high-risk metastases. We compared our framework against established methods and biomarkers using univariate and multivariate Cox regression. Our segmentation pipeline achieves median Dice scores of 0.96 (liver) and 0.93 (spleen), driving a CRLM segmentation Dice score of 0.78 and a detection F1-score of 0.79. Accurate segmentation enables our radiomics pipeline to achieve a survival prediction C-index of 0.69. Our results show the potential of integrating segmentation algorithms with radiomics-based survival analysis to deliver accurate and automated CRLM outcome prediction.
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