arXiv:2603.12581eess.IVcs.AI2026-03被引 2

通过解耦结构与风格,实现多模态MRI图像的精准重建。

Multiscale Structure-Guided Latent Diffusion for Multimodal MRI Translation

  • 在隐空间解耦模态风格与共享结构,提升重建一致性。
  • 多尺度建模低频解剖布局与高频边界细节,保持结构完整。
  • 适用于任意缺失模态场景,适合医学图像合成研究者。

尽管扩散模型在多模态磁共振成像(MRI)转换任务中取得了显著进展,现有方法在处理任意缺失模态场景时仍易出现解剖不一致或纹理细节退化问题。为此,我们提出一种基于隐空间扩散的多模态MRI转换框架——MSG-LDM。该方法利用可用模态推断完整结构信息,保留可靠的边界细节。具体而言,在隐空间引入风格-结构解耦机制,显式分离模态特有风格特征与共享结构表征,并在多尺度特征空间中联合建模低频解剖布局与高频边界细节。在结构解耦阶段,显式融入高频结构信息以增强特征表示,引导模型关注细粒度结构线索,同时学习模态不变的低频解剖表示。此外,为减少模态特定风格干扰并提升结构表示稳定性,设计了风格一致性损失与结构感知损失。在BraTS2020和WMH数据集上的大量实验表明,所提方法优于现有MRI合成方法,尤其在完整结构重建方面表现突出。源代码已公开于https://github.com/ziyi-start/MSG-LDM。

原文摘要 · Abstract (English)

Although diffusion models have achieved remarkable progress in multi-modal magnetic resonance imaging (MRI) translation tasks, existing methods still tend to suffer from anatomical inconsistencies or degraded texture details when handling arbitrary missing-modality scenarios. To address these issues, we propose a latent diffusion-based multi-modal MRI translation framework, termed MSG-LDM. By leveraging the available modalities, the proposed method infers complete structural information, which preserves reliable boundary details. Specifically, we introduce a style--structure disentanglement mechanism in the latent space, which explicitly separates modality-specific style features from shared structural representations, and jointly models low-frequency anatomical layouts and high-frequency boundary details in a multi-scale feature space. During the structure disentanglement stage, high-frequency structural information is explicitly incorporated to enhance feature representations, guiding the model to focus on fine-grained structural cues while learning modality-invariant low-frequency anatomical representations. Furthermore, to reduce interference from modality-specific styles and improve the stability of structure representations, we design a style consistency loss and a structure-aware loss. Extensive experiments on the BraTS2020 and WMH datasets demonstrate that the proposed method outperforms existing MRI synthesis approaches, particularly in reconstructing complete structures. The source code is publicly available at https://github.com/ziyi-start/MSG-LDM.

MRI生成扩散模型结构解耦医学影像

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