用差分隐私保护数据,实现多机构心脑血管风险预测的稳定模型。
A Robust Framework for Secure Cardiovascular Risk Prediction: An Architectural Case Study of Differentially Private Federated Learning
- 在服务器端引入动态优化机制,抑制噪声影响
- 在隐私预算ε≈13.4下保持F1=0.78、AUC=0.96
- 适合需要跨机构协作且严守隐私的医疗AI场景
精准的心血管风险预测对预防医学至关重要,但临床数据分散于各机构,受严格隐私法规限制,阻碍了鲁棒人工智能模型的发展。本文通过系统工程分析,验证了隐私保护联邦学习框架FedCVR在异构临床网络中的工程鲁棒性。重点评估了以效用优先的差分隐私(DP)下,服务器端自适应优化的运行权衡。在高保真合成环境中模拟真实数据集(Framingham、Cleveland)的特征空间与临床背景,系统评估了该架构对统计噪声的抗性。结果表明,集成服务器端动量作为时序去噪器后,系统在隐私预算ε≈13.4下仍能稳定达到F1分数0.78、曲线下面积(AUC)0.96,优于无隐私保护基线(F1=0.84)。FedCVR在相同隐私约束下显著优于标准无状态基线(FedAvg、FedProx)及其他自适应优化器(FedAdagrad、FedYogi)。研究证实,服务器端自适应是恢复真实隐私预算下临床实用性的结构性前提,为安全的多机构协作提供了可验证的工程蓝图。
原文摘要 · Abstract (English)
Accurate cardiovascular risk prediction is crucial for preventive healthcare; however, the development of robust Artificial Intelligence (AI) models is hindered by the fragmentation of clinical data across institutions due to stringent privacy regulations. This paper presents a comprehensive architectural case study validating the engineering robustness of FedCVR, a privacy-preserving Federated Learning framework applied to heterogeneous clinical networks. Rather than proposing a new theoretical optimizer, this work focuses on a systems engineering analysis to quantify the operational trade-offs of server-side adaptive optimization under utility-prioritized Differential Privacy (DP). By conducting a rigorous stress test in a high-fidelity synthetic environment that reflects the feature space and clinical context of real-world datasets (Framingham, Cleveland), we systematically evaluate the system's resilience to statistical noise. The validation results demonstrate that integrating server-side momentum as a temporal denoiser enables the architecture to achieve a stable F1 score of 0.78 and an Area Under the Curve (AUC) of 0.96 under the operational privacy budget (epsilon approximately 13.4), compared to a non-private baseline with an F1 score of 0.84. FedCVR statistically outperforms standard stateless baselines (FedAvg, FedProx) and other adaptive optimizers (FedAdagrad, FedYogi) under identical privacy constraints. Our findings confirm that server-side adaptivity is a structural prerequisite for recovering clinical utility under realistic privacy budgets, providing a validated engineering blueprint for secure multi-institutional collaboration.
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