提出新型图神经网络,提升脑发育障碍诊断准确性与可解释性。
LUMINA: Laplacian-Unifying Mechanism for Interpretable Neurodevelopmental Analysis via Quad-Stream GCN
- 采用四流图卷积结构与双谱拉普拉斯滤波,保留复杂神经连接动态
- 在ADHD200和ABIDE数据集上准确率达84.66%和88.41%
- 突破传统GCN平滑过度问题,适合临床神经疾病研究者使用
功能性磁共振成像(fMRI)已成为测量脑活动的经典方法,近期趋势转向利用fMRI数据进行AI驱动的诊断。由于大脑功能是一个连续互联的整体,以图卷积网络(GCN)为代表的图基架构成为主流,因其能将脑区(ROIs)视为动态互连节点并提取其关系结构。然而,GCN的数学基础反而成为性能瓶颈:反复平滑连接节点特征会模糊对识别神经障碍至关重要的对比动态。为此,我们提出LUMINA——一种用于可解释神经发育分析的拉普拉斯统一机制。该模型为四流GCN,采用双极ReLU激活和双谱图拉普拉斯滤波机制,有效捕捉传统GCN中常被掩盖的异质动态。通过在ADHD200(N=144)和ABIDE(N=579)数据集上的五折交叉验证,LUMINA在两种关键儿童神经发育障碍(注意力缺陷多动障碍和自闭症谱系障碍)诊断中表现稳定,准确率分别达到84.66%和88.41%,优于现有模型。
原文摘要 · Abstract (English)
Functional Magnetic Resonance Imaging(fMRI) has now become a classic way for measuring brain activity, and recent trend is shifting toward utilizing fMRI brain data for AI-driven diagnosis. Given that the brain functions as not a discrete but interconnected whole, Graph-based architectures represented by Graph Convolutional Network(GCN) has emerged as a dominant framework for such task, since they are capable of treating ROIs as dynamically interconnected nodes and extracting relational architecture between them. Ironically, however, it is the very nature of GCN's architecture that acts as an obstacle to its performance. The mathematical foundation of GCN, effective for capturing global regularities, acts as a tradeoff; by smoothing features across the connected nodes repeatedly, traditional GCN tend to blur out the contrastive dynamics that might be crucial in identifying certain neurological disorders. In order to break through this structural bottleneck, we propose LUMINA, a Laplacian-Unifying Mechanism for Interpretable Neurodevelopmental Analysis. Our model is a Quad-Stream GCN that employs a bipolar RELU activation and a dual-spectrum graph Laplacian filtering mechanism, thereby capturing heterogeneous dynamics that were often blurred out in conventional GCN. By doing so, we can preserve the diverse range and characteristics of neural connections in each fMRI data. Through 5-fold cross validation on the ADHD200(N=144) and ABIDE(N=579) dataset, LUMINA demonstrates stable diagnostic performance in two of the most critical neurodevelopmental disorder in childhood, ADHD and ASD, outperforming existing models with an accuracy of 84.66% and 88.41% each.
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