用DINOv3模型实现精准颈动脉厚度测量,支持测试时校准。
DINOv3 with Test-Time Calibration for Automated Carotid Intima-Media Thickness Measurement on CUBS v1
- 基于DINOv3构建分割与测量一体化框架,固定分辨率预测边界。
- 测试集平均Dice达0.774,CIMT绝对误差181.16μm,相关性0.480。
- 引入测试时校准降低误差至101.1μm,适合临床实用场景。
颈动脉内膜中层厚度(CIMT)是超声B模式图像中的重要血管生物标志物,用于评估动脉粥样硬化和心血管风险分层。尽管已有多种计算机化方法用于颈动脉边界分割与厚度估算,但能同时处理分割与测量的鲁棒、可迁移深度模型仍较少,尤其是在视觉基础模型兴起背景下。本文研究基于DINOv3的框架,在Carotid Ultrasound Boundary Study (CUBS) v1数据集上实现颈动脉内膜-中层复合体分割及后续CIMT测量。该流程在固定图像分辨率下预测内膜-中层带,列方向提取上下边界,利用CUBS提供的每图校准因子修正图像缩放影响,并输出物理单位下的CIMT值。在三个患者级测试划分中,平均测试Dice为0.7739 ± 0.0037,IoU为0.6384 ± 0.0044;平均CIMT绝对误差为181.16 ± 11.57 μm,皮尔逊相关系数为0.480 ± 0.259。在保留验证子集(n=28)中,测试时阈值校准将平均绝对误差从默认阈值下的141.0 μm降至优化阈值下的101.1 μm,同时系统偏差趋近于零。相较原始CUBS基准中经典方法的误差范围,本方法结果处于临床相关的约0.1 mm测量精度区间。结果表明,视觉基础模型可用于可解释、校准感知的CIMT测量。
原文摘要 · Abstract (English)
Carotid intima-media thickness (CIMT) measured from B-mode ultrasound is an established vascular biomarker for atherosclerosis and cardiovascular risk stratification. Although a wide range of computerized methods have been proposed for carotid boundary delineation and CIMT estimation, robust and transferable deep models that jointly address segmentation and measurement remain underexplored, particularly in the era of vision foundation models. Motivated by recent advances in adapting DINOv3 to medical segmentation and exploiting DINOv3 in test-time optimization pipelines, we investigate a DINOv3-based framework for carotid intima-media complex segmentation and subsequent CIMT measurement on the Carotid Ultrasound Boundary Study (CUBS) v1 dataset. Our pipeline predicts the intima-media band at a fixed image resolution, extracts upper and lower boundaries column-wise, corrects for image resizing using the per-image calibration factor provided by CUBS, and reports CIMT in physical units. Across three patient-level test splits, our method achieved a mean test Dice of 0.7739 $\pm$ 0.0037 and IoU of 0.6384 $\pm$ 0.0044. The mean CIMT absolute error was 181.16 $\pm$ 11.57 $μ$m, with a mean Pearson correlation of 0.480 $\pm$ 0.259. In a held-out validation subset ($n=28$), test-time threshold calibration reduced the mean absolute CIMT error from 141.0 $μ$m at the default threshold to 101.1 $μ$m at the measurement-optimized threshold, while simultaneously reducing systematic bias toward zero. Relative to the error ranges reported in the original CUBS benchmark for classical computerized methods, these results place a DINOv3-based approach within the clinically relevant $\sim$0.1 mm measurement regime. Together, our findings support the feasibility of using vision foundation models for interpretable, calibration-aware CIMT measurement.
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