用动态脑图解释痴呆患者脑连接异常,结果清晰可懂。
EEG-SeeGraph: Interpreting functional connectivity disruptions in dementias via sparse-explanatory dynamic EEG-graph learning
- 构建动态脑图模型,通过节点与边的双流编码捕捉脑区活动和连接变化。
- 采用节点引导的稀疏边掩码,仅保留关键连接,提升诊断可信度。
- 解释结果与临床已知发现一致,适合神经科医生辅助诊断使用。
从嘈杂、非平稳的脑电图(EEG)中实现稳健且可解释的痴呆诊断在临床上至关重要,但依然面临挑战。为此,我们提出SeeGraph,一种稀疏解释性动态脑电图图网络,能够建模随时间演化的功能连接,并利用节点引导的稀疏边掩码揭示驱动诊断决策的关键连接,同时对噪声和跨站点差异具有鲁棒性。SeeGraph包含四个组件:(1) 双轨迹时序编码器,通过两条路径分别捕捉区域振荡(节点信号)与区域间耦合(边信号);(2) 图谱感知位置编码器,基于融合后的连接结构生成图谱拉普拉斯坐标,增强节点嵌入;(3) 节点引导的稀疏解释性边掩码,将连接信息压缩为紧凑子图;(4) 门控图预测器,在稀疏化图上进行分类。模型通过交叉熵损失与掩码稀疏正则化联合训练,实现抗噪且可解释的诊断。在公开及自建的脑电图队列上验证了有效性,涵盖神经退行性痴呆患者与健康对照组,覆盖原始数据与噪声扰动条件。其稀疏、节点引导的解释结果突出了疾病相关连接,与既有的临床功能连接改变发现高度一致,为神经评估提供透明依据。
原文摘要 · Abstract (English)
Robust and interpretable dementia diagnosis from noisy, non-stationary electroencephalography (EEG) is clinically essential yet remains challenging. To this end, we propose SeeGraph, a Sparse-Explanatory dynamic EEG-graph network that models time-evolving functional connectivity and employs a node-guided sparse edge mask to reveal the connections that drive diagnostic decisions, while remaining robust to noise and cross-site variability. SeeGraph comprises four components: (1) a dual-trajectory temporal encoder that models dynamic EEG with two streams, where node signals capture regional oscillations and edge signals capture interregional coupling; (2) a topology-aware positional encoder that derives graph-spectral Laplacian coordinates from the fused connectivity and augments node embeddings; (3) a node-guided sparse explanatory edge mask that gates the connectivity into a compact subgraph; and (4) a gated graph predictor that operates on the sparsified graph. The framework is trained using cross-entropy loss together with a sparsity regularizer on the mask, yielding noise-robust and interpretable diagnoses. The effectiveness of SeeGraph is validated on public and in-house EEG cohorts, including patients with neurodegenerative dementias and healthy controls, under both raw and noise-perturbed conditions. Its sparse, node-guided explanations highlight disease-relevant connections and align with established clinical findings on functional connectivity alterations, thereby offering transparent cues for neurological evaluation.
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