arXiv:2603.21086cs.CV2026-03

通过分歧引导精炼,提升脑肿瘤分割的准确性与不确定性评估

DGRNet: Disagreement-Guided Refinement for Uncertainty-Aware Brain Tumor Segmentation

  • 用多视角差异估计不确定度,单次前向传播即可实现
  • 在TextBraTS数据集上Dice提升2.4%,HD95降低11%
  • 结合放射科报告精修模糊区域,适合临床决策支持场景

从MRI扫描中准确分割脑肿瘤对诊断和治疗规划至关重要。尽管深度学习方法表现优异,但仍存在两大根本局限:(1) 单模型预测缺乏可靠的不确定性量化,而不确定性水平可能影响治疗决策;(2) 未充分利用放射科报告中的丰富信息来指导模糊区域的分割。本文提出分歧引导精炼网络(DGRNet),通过多视角分歧的不确定性估计与文本条件精炼,同时解决上述问题。DGRNet通过共享编码器-解码器连接四个轻量级视图专用适配器生成多样预测,在单次前向传播中实现高效不确定性量化。随后构建分歧图识别高不确定性区域,并根据临床报告进行选择性精修。此外,引入多样性保持训练策略,结合成对相似性惩罚与梯度隔离,防止视图坍缩。在TextBraTS数据集上的实验表明,DGRNet在主指标Dice和HD95上分别较现有最优方法提升2.4%和11%,同时提供有意义的不确定性估计。

原文摘要 · Abstract (English)

Accurate brain tumor segmentation from MRI scans is critical for diagnosis and treatment planning. Despite the strong performance of recent deep learning approaches, two fundamental limitations remain: (1) the lack of reliable uncertainty quantification in single-model predictions, which is essential for clinical deployment because the level of uncertainty may impact treatment decision-making, and (2) the under-utilization of rich information in radiology reports that can guide segmentation in ambiguous regions. In this paper, we propose the Disagreement-Guided Refinement Network (DGRNet), a novel framework that addresses both limitations through multi-view disagreement-based uncertainty estimation and text-conditioned refinement. DGRNet generates diverse predictions via four lightweight view-specific adapters attached to a shared encoder-decoder, enabling efficient uncertainty quantification within a single forward pass. Afterward, we build disagreement maps to identify regions of high segmentation uncertainty, which are then selectively refined according to clinical reports. Moreover, we introduce a diversity-preserving training strategy that combines pairwise similarity penalties and gradient isolation to prevent view collapse. The experimental results on the TextBraTS dataset show that DGRNet favorably improves state-of-the-art segmentation accuracy by 2.4% and 11% in main metrics Dice and HD95, respectively, while providing meaningful uncertainty estimates.

脑肿瘤分割不确定性估计多模态融合医学图像

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