arXiv:2603.24764cs.CVcs.LG2026-03

用生成模型合成心脏MRI,解决数据少、隐私差问题。

Synthetic Cardiac MRI Image Generation using Deep Generative Models

  • 用分割图引导生成,提升解剖结构准确性。
  • 扩散与流匹配模型能更好保留边界,生成更真实图像。
  • 适合需要多厂商兼容数据的医学影像研究者。

合成心脏磁共振成像(CMRI)已成为缓解标注医学影像数据稀缺的有力策略。生成对抗网络(GANs)、变分自编码器(VAEs)、扩散概率模型及流匹配技术等近年进展,在应对标注数据有限、设备厂商差异及模型记忆导致的隐私泄露风险方面表现突出。通过分割图条件化生成可提高解剖结构保真度;扩散与流匹配模型具备强边界保持能力,支持高效确定性变换。跨域泛化通过厂商风格条件化与强度归一化等预处理步骤进一步增强。为保障隐私,研究日益引入成员推理攻击、最近邻分析和差分隐私机制。效用评估通常以下游分割性能为指标,证据表明,受解剖约束的合成数据可提升多厂商场景下的准确性和鲁棒性。本文旨在从保真度、效用与隐私角度比较现有CMRI生成方法,指出当前局限,并强调需构建集成、评估驱动的框架以实现可靠的临床应用。

原文摘要 · Abstract (English)

Synthetic cardiac MRI (CMRI) generation has emerged as a promising strategy to overcome the scarcity of annotated medical imaging data. Recent advances in GANs, VAEs, diffusion probabilistic models, and flow-matching techniques aim to generate anatomically accurate images while addressing challenges such as limited labeled datasets, vendor variability, and risks of privacy leakage through model memorization. Maskconditioned generation improves structural fidelity by guiding synthesis with segmentation maps, while diffusion and flowmatching models offer strong boundary preservation and efficient deterministic transformations. Cross-domain generalization is further supported through vendor-style conditioning and preprocessing steps like intensity normalization. To ensure privacy, studies increasingly incorporate membership inference attacks, nearest-neighbor analyses, and differential privacy mechanisms. Utility evaluations commonly measure downstream segmentation performance, with evidence showing that anatomically constrained synthetic data can enhance accuracy and robustness across multi-vendor settings. This review aims to compare existing CMRI generation approaches through the lenses of fidelity, utility, and privacy, highlighting current limitations and the need for integrated, evaluation-driven frameworks for reliable clinical workflows.

医学影像生成模型隐私保护心脏MRI

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