用多智能体模拟医生思维,动态推理提升诊断准确率
ClinicalAgents: Multi-Agent Orchestration for Clinical Decision Making with Dual-Memory

- 构建双记忆架构,动态维护患者状态并调用历史病例与指南
- 通过蒙特卡洛树搜索实现迭代假设与证据验证,支持回溯修正
- 相比单/多智能体基线,诊断准确率显著提升,结果更可解释
尽管大语言模型在医疗领域展现出潜力,但在复杂、非线性的临床诊断推理中仍表现不足。现有方法多依赖静态的线性映射,难以捕捉人类医生迭代式、假设驱动的推理过程。为此,我们提出ClinicalAgents,一种模拟专家医生认知流程的多智能体框架。该框架采用基于蒙特卡洛树搜索(MCTS)的动态编排机制,使协调器能持续生成假设、主动验证证据,并在关键信息缺失时触发回溯。其核心是双记忆结构:可变的工作记忆用于保持演进中的患者状态以实现上下文感知推理,静态的经验记忆则通过主动反馈循环检索临床指南与历史案例。大量实验表明,ClinicalAgents在所评估基线中表现最优,显著提升了诊断准确率与可解释性。代码已开源:https://github.com/ZhuohanGe/ClinicalAgents-Code。
原文摘要 · Abstract (English)
While Large Language Models (LLMs) have demonstrated potential in healthcare, they often struggle with the complex, non-linear reasoning required for accurate clinical diagnosis. Existing methods typically rely on static, linear mappings from symptoms to diagnoses, failing to capture the iterative, hypothesis-driven reasoning inherent in human clinicians. To bridge this gap, we introduce ClinicalAgents, a novel multi-agent framework designed to simulate the cognitive workflow of expert clinicians. Unlike rigid sequential chains, ClinicalAgents employs a dynamic orchestration mechanism modeled as a Monte Carlo Tree Search (MCTS) process. This allows an orchestrator to iteratively generate hypotheses, actively verify evidence, and trigger backtracking when critical information is missing. The foundation of this framework is a Dual-Memory architecture: a mutable working memory that maintains the evolving patient state for context-aware reasoning, and a static experience memory that retrieves clinical guidelines and historical cases via an active feedback loop. Extensive experiments demonstrate that ClinicalAgents achieves the best performance among evaluated baselines, significantly enhancing both diagnostic accuracy and explainability compared to strong single-agent and multi-agent baselines. Our code is released at https://github.com/ZhuohanGe/ClinicalAgents-Code.
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