用图注意力网络分析脑连接,准确率超88%,助力自闭症早期筛查。
Graph Attention Network-Based Detection of Autism Spectrum Disorder
- 基于fMRI构建脑区连接图,用图注意力网络识别关键连接模式。
- 30次独立实验平均准确率达88.79%,比基准模型高12.27%。
- 揭示了已知与新发现的自闭症相关脑区,模型可推广至复杂关系分析。
自闭症谱系障碍(ASD)是一种神经发育障碍,以大脑连接异常为特征。早期检测是应对该疾病的关键步骤。本研究提出一种新型计算框架——基于注意力机制的图卷积网络GATGraphClassifier,用于检测ASD。我们利用自闭症脑成像数据交换(ABIDE)数据库中的功能磁共振成像(fMRI)数据,通过皮尔逊相关性构建功能连接矩阵,表征不同脑区间的交互关系。这些矩阵被转换为图结构,其中节点代表脑区,边代表功能连接。GATGraphClassifier采用注意力机制,识别关键连接模式,提升模型可解释性与诊断准确性。在所有标准分类指标上,本框架均优于现有最先进方法。在30次独立运行中,测试集平均准确率达到88.79%,较基准模型提升12.27%。同时,我们识别出与ASD相关的关键脑区,与先前研究一致,并发现了若干新关联区域。本研究不仅推动了自闭症检测技术发展,也展示了GATGraphClassifier在分析复杂关系数据方面的广泛应用潜力。
原文摘要 · Abstract (English)
Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by atypical brain connectivity. One of the crucial steps in addressing ASD is its early detection. This study introduces a novel computational framework that employs an Attention-Based Graph Convolutional Network, referred to as the GATGraphClassifier, for detecting ASD. We utilize Functional Magnetic Resonance Imaging (fMRI) data from the Autism Brain Imaging Data Exchange (ABIDE) repository to construct functional connectivity matrices using Pearson correlation, which captures interactions between various brain regions. These matrices are then transformed into graph representations, where the nodes and edges represent the brain regions and functional connections, respectively. The GATGraphClassifier employs attention mechanisms to identify critical connectivity patterns, thereby enhancing the model's interpretability and diagnostic accuracy. Our proposed framework demonstrates superior performance across all standard classification metrics compared to existing state-of-the-art methods. Notably, we achieved an average accuracy of 88.79\% on the test data over 30 independent runs, surpassing the benchmark model's performance by 12.27\%. In addition, we identified the crucial brain regions associated with ASD, consistent with the previous studies, and a few novel regions. This study not only contributes to the advancement of ASD detection but also shows the potential for broader adaptability of GATGraphClassifier in analyzing complex relational data in various fields, where understanding intricate connectivity and interaction patterns is essential.
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