用手机摄像头定量检测生物化学浓度，助力偏远地区无创检测
Quantitative measurements of biological/chemical concentrations using smartphone cameras
- 构建颜色与浓度映射数据库，通过手机摄像头采集图像
- 对荧光物质和胶体混合物的浓度测量精度接近商用仪器
- 适合资源匮乏地区快速诊断，具低成本便携优势
本文提出一种基于智能手机的成像系统，可定量分析多种生物/化学检测试剂的浓度。核心目标是建立一个图像数据库，刻画颜色信息与样品浓度之间的关系。为此，设计了专用光学装置，并结合图像处理与数据分析技术。在荧光素、RNA Mango、均质牛奶及酵母等样本上的实验表明，该系统对荧光材料和胶体混合物的浓度估计精度与现有商用及实验室设备相当。借助智能手机的摄像头与计算能力，未来有望发展为极紧凑、低成本、便携式的分析与诊断系统，使远程或贫困地区的检测成为可能。
原文摘要 · Abstract (English)
This paper presents a smartphone-based imaging system capable of quantifying the concentration of an assortment of biological/chemical assay samples. The main objective is to construct an image database which characterizes the relationship between color information and concentrations of the biological/chemical assay sample. For this aim, a designated optical setup combined with image processing and data analyzing techniques was implemented. A series of experiments conducted on selected assays, including fluorescein, RNA Mango, homogenized milk and yeast have demonstrated that the proposed system estimates the concentration of fluorescent materials and colloidal mixtures comparable to currently used commercial and laboratory instruments. Furthermore, by utilizing the camera and computational power of smartphones, eventual development can be directed toward extremely compact, inexpensive and portable analysis and diagnostic systems which will allow experiments and tests to be conducted in remote or impoverished areas.
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