面对临床证据矛盾,CARE框架在保护隐私前提下提升大模型决策准确性。
CARE: Privacy-Compliant Agentic Reasoning with Evidence Discordance

- 分阶段设计:外部大模型生成结构化推理路径,本地模型据此采集证据并决策。
- 在MIMIC-DOS数据集上,CARE在多个关键指标上优于现有方法。
- 适合医疗高风险场景,兼顾隐私保护与冲突证据处理能力。
大型语言模型(LLM)系统日益用于高风险决策,但在证据内部不一致时表现下降。此类情况在真实医疗环境中常见,如患者自述症状与体征矛盾。为此,我们构建了MIMIC-DOS数据集,用于重症监护室(ICU)短期器官功能恶化预测,其来源为公开的MIMIC-IV,仅包含症状与体征存在矛盾的病例。该设定对现有基于LLM的方法构成严峻挑战,单次推理模型与代理流水线常难以调和冲突信号。为此,我们提出CARE:一种多阶段隐私合规的代理推理框架。其中,私有大模型生成结构化类别与状态转移规则,不接触敏感患者数据;本地大模型则利用这些规则进行证据获取与最终决策。在MIMIC-DOS上的受控回顾性评估显示,CARE在多项关键指标上表现最优,证明其能更稳健地处理冲突临床证据的同时保障隐私。
原文摘要 · Abstract (English)
Large language model (LLM) systems are increasingly used to support high-stakes decision-making, but they typically perform worse when the available evidence is internally inconsistent. Such a scenario exists in real-world healthcare settings, with patient-reported symptoms contradicting medical signs. To study this problem, we introduce MIMIC-DOS, a dataset for short-horizon organ dysfunction worsening prediction in the intensive care unit (ICU) setting. We derive this dataset from the widely recognized MIMIC-IV, a publicly available electronic health record dataset, and construct it exclusively from cases in which discordance between signs and symptoms exists. This setting poses a substantial challenge for existing LLM-based approaches, with single-pass LLMs and agentic pipelines often struggling to reconcile such conflicting signals. To address this problem, we propose CARE: a multi-stage privacy-compliant agentic reasoning framework in which a proprietary LLM provides guidance by generating structured categories and transitions without accessing sensitive patient data, while a local LLM uses these categories and transitions to support evidence acquisition and final decision-making. Empirically, under controlled retrospective evaluation on MIMIC-DOS, CARE achieves the best overall performance across key metrics among the evaluated LLMs and agentic workflows, showing that it can more robustly handle conflicting clinical evidence while preserving privacy.
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