arXiv:2604.01449cs.AIcs.LG2026-04被引 1

研究AI开药系统出错时的临床风险,揭示其真实可靠性隐患。

When AI Gets it Wrong: Reliability and Risk in AI-Assisted Medication Decision Systems

  • 通过模拟用药场景分析AI错误类型及成因
  • 错误可导致药物反应、治疗无效或延误诊疗
  • 强调需用风险意识评估替代单一性能指标

人工智能系统正越来越多地融入医疗与药房流程,辅助药物推荐、剂量确定和药物相互作用检测。尽管这些系统在标准评估指标下表现良好,但其在真实决策中的可靠性仍不明确。在高风险的用药管理领域,一次错误推荐就可能导致严重患者伤害。本文聚焦于AI辅助用药系统的故障及其潜在临床后果,不依赖整体性能指标,转而关注错误如何发生以及错误输出带来的影响。通过一系列控制性模拟实验,分析药物相互作用和剂量决策中的多种系统故障,包括遗漏相互作用、错误风险提示和不恰当剂量建议。结果表明,用药相关情境下的AI错误可能引发不良药物反应、治疗无效或延迟治疗,尤其在缺乏充分人工监督时更为显著。同时,论文讨论了对AI过度依赖的风险及决策过程透明度不足带来的挑战。本研究提出以可靠性为核心的医疗AI评估视角,强调理解系统失效行为与真实世界影响的重要性,呼吁在安全关键领域(如药房实践)补充传统性能指标,采用风险感知的评估方法。

原文摘要 · Abstract (English)

Artificial intelligence (AI) systems are increasingly integrated into healthcare and pharmacy workflows, supporting tasks such as medication recommendations, dosage determination, and drug interaction detection. While these systems often demonstrate strong performance under standard evaluation metrics, their reliability in real-world decision-making remains insufficiently understood. In high-risk domains such as medication management, even a single incorrect recommendation can result in severe patient harm. This paper examines the reliability of AI-assisted medication systems by focusing on system failures and their potential clinical consequences. Rather than evaluating performance solely through aggregate metrics, this work shifts attention towards how errors occur and what happens when AI systems produce incorrect outputs. Through a series of controlled, simulated scenarios involving drug interactions and dosage decisions, we analyse different types of system failures, including missed interactions, incorrect risk flagging, and inappropriate dosage recommendations. The findings highlight that AI errors in medication-related contexts can lead to adverse drug reactions, ineffective treatment, or delayed care, particularly when systems are used without sufficient human oversight. Furthermore, the paper discusses the risks of over-reliance on AI recommendations and the challenges posed by limited transparency in decision-making processes. This work contributes a reliability-focused perspective on AI evaluation in healthcare, emphasising the importance of understanding failure behavior and real-world impact. It highlights the need to complement traditional performance metrics with risk-aware evaluation approaches, particularly in safety-critical domains such as pharmacy practice.

AI医疗用药安全系统风险可靠性评估

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