arXiv:2604.01962cs.AIcs.LG2026-04

构建首个神经源性异常头动知识库,助力帕金森等疾病智能诊断。

Abnormal Head Movements in Neurological Conditions: A Knowledge-Based Dataset with Application to Cervical Dystonia

  • 通过多大模型抽取1430篇论文,构建57类疾病的头动数据集
  • 提出头颈严重程度指数,统一不同临床评分标准,验证率达6.7%
  • 可支持医生和研究者分析异常头动与病情关联,提升诊疗效率

异常头运动(AHMs)广泛存在于多种神经系统疾病中,但缺乏整合运动学数据、临床严重程度评分与患者人口统计信息的多病种资源,阻碍了基于AI的诊断工具发展。本研究提出NeuroPose-AHM,一个基于知识的神经源性异常头动数据集,通过多大语言模型框架从1,430篇同行评审论文中提取数据。该数据集包含2,756条患者组级记录,覆盖57种神经系统疾病,源自846篇相关论文。跨模型可靠性分析显示,研究级别分类一致性良好(kappa = 0.822)。为验证其分析价值,以痉挛性斜颈(CD)为例开展四任务框架:任务一实现多标签头动类型分类(F1 = 0.856);任务二构建头颈严重程度指数(HNSI),统一异构临床评分;任务三在真实患者数据中验证HNSI,严重程度比例一致(6.7%),初步支持指数校准;任务四揭示运动类型概率与HNSI得分显著相关(p < 0.001)。结果表明,NeuroPose-AHM是结构化、知识驱动的神经源性头动研究重要资源。数据集已公开于Zenodo(https://doi.org/10.5281/zenodo.19386862)。

原文摘要 · Abstract (English)

Abnormal head movements (AHMs) manifest across a broad spectrum of neurological disorders; however, the absence of a multi-condition resource integrating kinematic measurements, clinical severity scores, and patient demographics constitutes a persistent barrier to the development of AI-driven diagnostic tools. To address this gap, this study introduces NeuroPose-AHM, a knowledge-based dataset of neurologically induced AHMs constructed through a multi-LLM extraction framework applied to 1,430 peer-reviewed publications. The dataset contains 2,756 patient-group-level records spanning 57 neurological conditions, derived from 846 AHM-relevant papers. Inter-LLM reliability analysis confirms robust extraction performance, with study-level classification achieving strong agreement (kappa = 0.822). To demonstrate the dataset's analytical utility, a four-task framework is applied to cervical dystonia (CD), the condition most directly defined by pathological head movement. First, Task 1 performs multi-label AHM type classification (F1 = 0.856). Task 2 constructs the Head-Neck Severity Index (HNSI), a unified metric that normalizes heterogeneous clinical rating scales. The clinical relevance of this index is then evaluated in Task 3, where HNSI is validated against real-world CD patient data, with aligned severe-band proportions (6.7%) providing a preliminary plausibility indication for index calibration within the high severity range. Finally, Task 4 performs bridge analysis between movement-type probabilities and HNSI scores, producing significant correlations (p less than 0.001). These results demonstrate the analytical utility of NeuroPose-AHM as a structured, knowledge-based resource for neurological AHM research. The NeuroPose-AHM dataset is publicly available on Zenodo (https://doi.org/10.5281/zenodo.19386862).

异常头动神经疾病数据集人工智能

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