用Transformer无监督检测步态异常并修复,无需疾病标签。
GenGait: A Transformer-Based Model for Human Gait Anomaly Detection and Normative Twin Generation
- 基于正常步态数据训练Transformer掩码自编码器,无须疾病标签。
- 可准确定位异常关节,显著降低角度偏差(大效应量)。
- 适合临床步态分析、康复评估,结果可解释性强。
步态分析能客观描述运动功能,广泛用于神经与骨科疾病的诊断和康复监测。深度学习虽被广泛应用,但多数方法依赖带病状标签的监督分类,难以泛化到多样的病理表现。本文提出一种无标签框架,通过仅使用150名成人正常步态序列(基于无标记多摄像机系统采集)训练的Transformer掩码自编码器,实现关节级异常检测与运动学修正。推理时采用两阶段流程:先通过遮蔽单个关节并测量其与学习到的正常先验的偏差,估算关节不一致得分;再将标记出的关节从编码器输入中移除,利用剩余时空上下文重建完整骨架,得到异常位置的修正运动轨迹。在10名保留的正常参与者模仿7种模拟步态异常的验证中,该方法准确识别生物力学不一致的关节,所有分析关节的角度偏差显著降低,且保持正常运动学特征。该方法可在无需疾病标签的情况下,实现可解释、个体化的步态损伤定位。视频见https://youtu.be/Rcm3jqR5pN4。
原文摘要 · Abstract (English)
Gait analysis provides an objective characterization of locomotor function and is widely used to support diagnosis and rehabilitation monitoring across neurological and orthopedic disorders. Deep learning has been increasingly applied to this domain, yet most approaches rely on supervised classifiers trained on disease-labeled data, limiting generalization to heterogeneous pathological presentations. This work proposes a label-free framework for joint-level anomaly detection and kinematic correction based on a Transformer masked autoencoder trained exclusively on normative gait sequences from 150 adults, acquired with a markerless multi-camera motion-capture system. At inference, a two-pass procedure is applied to potentially pathological input sequences, first it estimates joint inconsistency scores by occluding individual joints and measuring deviations from the learned normative prior. Then, it withholds the flagged joints from the encoder input and reconstructs the full skeleton from the remaining spatiotemporal context, yielding corrected kinematic trajectories at the flagged positions. Validation on 10 held-out normative participants, who mimicked seven simulated gait abnormalities, showed accurate localization of biomechanically inconsistent joints, a significant reduction in angular deviation across all analyzed joints with large effect sizes, and preservation of normative kinematics. The proposed approach enables interpretable, subject-specific localization of gait impairments without requiring disease labels. Video is available at https://youtu.be/Rcm3jqR5pN4.
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