arXiv:2604.11178q-bio.NCcs.LG2026-04

用自回归流匹配模型,概率预测大脑对自然刺激的神经反应。

Probabilistic Prediction of Neural Dynamics via Autoregressive Flow Matching

  • 基于自回归流匹配,建模神经活动随时间演化的条件分布。
  • 在阿尔戈纳特2025数据集上,短时预测精度显著优于基线模型。
  • 适合关注闭环神经技术与高维神经动力学建模的研究者。

预测大脑对自然刺激的神经活动仍是理解脑动态及推动神经技术应用的关键挑战。本文提出一种基于自回归流匹配(AFM)的生成式预测框架,从多模态感官输入中概率性地大规模预测神经反应。具体而言,学习给定过去神经动态和同步感官输入下未来神经活动的条件分布,显式建模神经活动为依赖近期历史的时间演化过程。我们在阿尔戈纳特2025项目功能性磁共振成像数据集上,采用个体化模型进行评估。AFM在短时区域级血氧水平依赖(BOLD)活动预测上显著优于非自回归流匹配基线和官方挑战的广义线性模型基线,展现出更强泛化能力与广泛皮层预测性能。消融分析表明,过去BOLD动态是性能提升的主要驱动因素,而自回归分解在短时、上下文丰富的条件下带来一致且小幅的增益。这些结果表明,基于自回归流的生成建模是短期神经动力学概率预测的有效方法,在闭环神经技术中有广阔应用前景。

原文摘要 · Abstract (English)

Forecasting neural activity in response to naturalistic stimuli remains a key challenge for understanding brain dynamics and enabling downstream neurotechnological applications. Here, we introduce a generative forecasting framework for modeling neural dynamics based on autoregressive flow matching (AFM). Building on recent advances in transport-based generative modeling, our approach probabilistically predicts neural responses at scale from multimodal sensory input. Specifically, we learn the conditional distribution of future neural activity given past neural dynamics and concurrent sensory input, explicitly modeling neural activity as a temporally evolving process in which future states depend on recent neural history. We evaluate our framework on the Algonauts project 2025 challenge functional magnetic resonance imaging dataset using subject-specific models. AFM significantly outperforms both a non-autoregressive flow-matching baseline and the official challenge general linear model baseline in predicting short-term parcel-wise blood oxygenation level-dependent (BOLD) activity, demonstrating improved generalization and widespread cortical prediction performance. Ablation analyses show that access to past BOLD dynamics is a dominant driver of performance, while autoregressive factorization yields consistent, modest gains under short-horizon, context-rich conditions. Together, these findings position autoregressive flow-based generative modeling as an effective approach for short-term probabilistic forecasting of neural dynamics with promising applications in closed-loop neurotechnology.

神经动力学生成模型自回归脑机接口

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