只需标注中心切片,快速生成乳腺断层摄影密集组织分割图
A Workflow to Efficiently Generate Dense Tissue Ground Truth Masks for Digital Breast Tomosynthesis
- 仅需在中央切片勾画大致区域并设阈值,自动推导全体积分割
- 对44例数据测试,与放射科医生标注的平均相似度达0.83
- 适合需要高效生成训练标签的研究者,尤其关注乳腺影像分析
数字乳腺断层摄影(DBT)已成为美国乳腺癌筛查的标准。准确分割DBT图像中的纤维腺体组织对个性化风险评估至关重要,但算法开发受限于稀缺的人工标注训练数据。本研究提出一种省时省力的框架,用于生成DBT中密集组织的二值分割掩膜。用户仅需在DBT体数据的中心重建切片上勾画包含密集组织的粗略兴趣区(ROI),并选择分割阈值,算法将该ROI投影至其余切片,并迭代调整各切片阈值,以保持全体积内密集组织轮廓的一致性。通过仅需在中心切片标注,显著降低标注时间和劳动成本。使用44个来自DBTex数据集的DBT体数据进行评估:两位放射科医生间的患者级骰子相似系数中位数为0.84;一名放射科医生手动分割每例数据的第20和第80百分位切片(CC和MLO视图;共176个切片),与所提方法的分割结果计算骰子分数,中位数为0.83。
原文摘要 · Abstract (English)
Digital breast tomosynthesis (DBT) is now the standard of care for breast cancer screening in the USA. Accurate segmentation of fibroglandular tissue in DBT images is essential for personalized risk estimation, but algorithm development is limited by scarce human-delineated training data. In this study we introduce a time- and labor-saving framework to generate a human-annotated binary segmentation mask for dense tissue in DBT. Our framework enables a user to outline a rough region of interest (ROI) enclosing dense tissue on the central reconstructed slice of a DBT volume and select a segmentation threshold to generate the dense tissue mask. The algorithm then projects the ROI to the remaining slices and iteratively adjusts slice-specific thresholds to maintain consistent dense tissue delineation across the DBT volume. By requiring annotation only on the central slice, the framework substantially reduces annotation time and labor. We used 44 DBT volumes from the DBTex dataset for evaluation. Inter-reader agreement was assessed by computing patient-wise Dice similarity coefficients between segmentation masks produced by two radiologists, yielding a median of 0.84. Accuracy of the proposed method was evaluated by having a radiologist manually segment the 20th and 80th percentile slices from each volume (CC and MLO views; 176 slices total) and calculate Dice scores between the manual and proposed segmentations, yielding a median of 0.83.
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