用预训练模型和脑结构约束,让头皮脑电逼近颅内脑电。
Bridging scalp and intracranial EEG in BCI via pretrained neural representations and geometric constraint embedding

- 融合预训练脑电表示与大脑解剖结构,建模信号传播机制。
- 生成的增强脑电信号有效恢复了深层神经活动模式。
- 适合脑机接口、神经工程研究者,可降低高精度信号获取成本。
脑电图(EEG)因时间分辨率高、无创、便携等优势,成为脑机接口(BCI)的关键技术。但其信噪比和空间分辨率远低于侵入式脑电图(iEEG),而后者因侵入性导致临床应用受限。为此,本文提出一种数据与先验知识驱动的统一框架,旨在提升脑电信号表征能力。基于“几何结构决定功能”原则,该框架将静态皮层解剖结构映射为动态信号传播的约束,并结合预训练大模型提取的通用神经表征,显式建模脑内信号传播过程。通过多维表示扩散过程,合成增强型脑电信号。大量实验证明,生成信号能有效恢复脑内传播中丢失的神经活动模式。结果表明,BCI性能上限不仅受硬件限制,更取决于生成模型对神经信号传播机制的解析深度。该框架为低成本获取高保真神经信号提供了可行路径。
原文摘要 · Abstract (English)
Electroencephalography (EEG) has become one of the key modalities underpinning brain-computer interfaces (BCIs) due to its high temporal resolution, rapid responsiveness, non-invasiveness, low cost, and portability. However, EEG signals are substantially inferior to intracranial EEG (iEEG) in signal-to-noise ratio and local spatial resolution, whereas iEEG suffers from extremely limited clinical accessibility owing to its invasive nature, hindering widespread application. To address this challenge, this study proposes a unified data-and prior knowledge-driven framework for EEG-iEEG representational enhancement. Guided by the principle that "geometric structure dictates function", the framework maps static cortical anatomy onto dynamic constraints governing neural signal propagation and integrates general-purpose neural representations extracted by a pre-trained large EEG model to explicitly model signal transmission through the brain. Enhanced EEG signals are then synthesized via a multidimensional representation diffusion process. Numerous experimental results demonstrate that the generated enhanced EEG signals effectively recover the neural activity patterns lost during propagation through the brain. This finding indicates that the performance ceiling of BCIs is constrained not only by acquisition hardware but also by the depth to which the generative model resolves the mechanisms of neural signal propagation. Collectively, the proposed framework provides a viable pathway toward acquiring high-fidelity neural signals at low cost.
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