arXiv:2604.22858cs.CV2026-04

发布肝癌病理量化资源,支持细粒度组织分析与自动评估

A Digital Pathology Resource for Liver Cancer Quantification with Datasets, Benchmarks, and Tools

论文配图:A Digital Pathology Resource for Liver Cancer Quantification with Datasets, Benchmarks, and Tools
图 1 · 摘自论文原文
  • 构建肝癌组织级标注数据集,含7类关键组织成分
  • 开发端到端定量工具HepatoQuant,实现从全切片到组分统计的自动化
  • 开源数据、模型与基准协议,推动肝癌病理智能分析发展

肝癌尤其是肝细胞癌(HCC)带来重大全球健康负担。准确诊断和预后评估直接影响治疗选择与生存率,而病理检查仍是肝癌诊断的金标准。在病理切片中识别多样化的组织成分和病理亚型,对估算术后复发风险和总体预后至关重要。然而,现有公开资源多以全切片图像(WSI)形式提供,缺乏精细标注的肝癌组织成分数据集,阻碍了可复现的模型开发与定量分析工具部署。为此,我们发布了HepatoBench——一个包含7个关键组织类别标注的肝癌病灶级图像数据库。基于此,我们训练并开源了一个深度学习分类模型作为组织识别工具;同时训练了全切片级别的肿瘤/非肿瘤分割模型,可自动定位整个切片中的病变区域。通过整合病灶级分类器与全切片分割模型,构建了端到端、疾病特异性的肝癌区域量化工具HepatoQuant,实现从全切片图像到组织构成解析与定量统计的统一工作流。我们还开源了HepatoBench数据集、基准测试协议及配套工具,为肝癌病理的自动化区域量化与公平方法比较提供坚实基础。

原文摘要 · Abstract (English)

Liver cancer, especially hepatocellular carcinoma (HCC), imposes a substantial global disease burden. Accurate diagnosis and prognostic assessment directly influence treatment selection and patient survival, and pathological examination remains the gold standard for liver cancer diagnosis. Identifying diverse tissue components and pathological subtypes on histopathology slides is crucial for estimating postoperative recurrence risk and overall prognosis. However, most publicly available resources are still provided at the whole-slide image (WSI) level, and well-annotated datasets for fine-grained tissue component identification in liver cancer are scarce, which hinders reproducible model development and the deployment of quantitative analysis tools. To address this gap, we release HepatoBench, a patch-level image database for liver cancer with annotations for seven key tissue categories. Based on HepatoBench, we train and open-source a deep learning classification model as a tissue recognition tool. Furthermore, we train a WSI-level tumor/non-tumor segmentation model to automatically localize lesion regions across entire slides. By integrating the patch-level tissue classifier with the WSI-level segmentation model, we build HepatoQuant, an end-to-end, disease-specific regional quantification tool for liver cancer, enabling a unified workflow from WSIs to tissue composition parsing and quantitative statistics. We also open-source HepatoBench, the benchmarking protocol, and supporting tools, providing a solid foundation for automated regional quantification and fair method comparison in liver cancer pathology.

数字病理肝癌组织分割定量分析

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