提出可泛化的无CT PET校正网络,提升儿童患者定量准确性。
Generalizable CT-Free PET Attenuation and Scatter Correction for Pediatric Patients

- 双域网络分离解剖结构与设备特异性噪声
- 在1085例儿科扫描中跨设备/示踪剂保持稳定精度
- 适合需要降低辐射暴露的儿科PET临床应用
基于CT的衰减与散射校正虽能提升定量PET性能,但会增加辐射暴露,尤其不适合儿童影像。现有无CT方法多在同质环境下训练,面对扫描仪或示踪剂变化时性能下降,限制了临床应用。本文提出通用化PET校正网络(GPCN),一种双域网络,实现对异构成像条件的鲁棒校正。GPCN结合多带上下文精修模块(通过小波多尺度分解和长程空间建模刻画儿童解剖变异性)与频域感知谱解耦模块(在傅里叶域进行坐标条件下的幅度/相位精修),通过多带空间上下文建模与非对称频谱解耦,显式分离不变拓扑结构与域特定噪声,实现对解剖器官与局灶病灶的精确定量恢复。在1085例使用两种扫描仪和五种示踪剂采集的儿科全身PET扫描上训练与评估,无论联合训练还是零样本跨域测试,GPCN均优于代表性基线,在未见扫描仪-示踪剂组合上保持稳定定量精度。消融实验、区域定量分析及下游分割任务进一步验证有效性。本队列中传统方案的CT部分平均有效剂量达10.8 mSv,凸显可靠无CT校正的临床价值。
原文摘要 · Abstract (English)
Computed tomography (CT)-based attenuation and scatter correction improves quantitative PET but adds radiation exposure that is particularly undesirable in pediatric imaging. Existing CT-free methods are commonly trained in homogeneous settings and often degrade under scanner or radiotracer shifts, which limits their clinical utility. We propose the Generalizable PET Correction Network (GPCN), a dual-domain network for domain-robust CT-free PET attenuation and scatter correction. GPCN combines a multi-band contextual refinement module, which models pediatric anatomical variability through wavelet-based multiscale decomposition and long-range spatial context modeling, with a frequency-aware spectral decoupling module, which performs coordinate-conditioned amplitude/phase refinement in the Fourier domain. By synergizing multi-band spatial contextual modeling with asymmetric frequency-spectrum decoupling, the network explicitly separates invariant topological structures from domain-specific noise, thereby achieving precise quantitative recovery of both anatomical organs and focal lesions. This design aims to separate anatomy-dominant structures from domain-sensitive spectral residuals and to improve robustness across heterogeneous imaging conditions. We train and evaluate the method on 1085 pediatric whole-body PET scans acquired with two scanners and five radiotracers. In both joint training and zero-shot cross-domain evaluation, GPCN outperforms representative baselines and maintains stable quantitative accuracy on unseen scanner-tracer combinations. The method is further supported by ablation, region-wise quantitative analysis, and downstream segmentation experiments. In our cohort, the CT component of the conventional protocol corresponded to an average effective dose of 10.8 mSv, indicating the potential clinical value of reliable CT-free correction for pediatric PET.
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