用语音动态的重复结构识别抑郁症,比传统方法更有效。
Recurrence-Based Nonlinear Vocal Dynamics as Digital Biomarkers for Depression Detection from Conversational Speech

- 将语音轨迹视为非线性系统,提取重复性特征
- 在142人数据集上达AUC 0.689,优于静态声学特征
- 适合心理疾病智能筛查与语音分析研究者
抑郁症的数字生物标志物主要依赖静态声学描述、汇总统计或传统机器学习表征,可能忽略对话中语音动态的非线性时间结构。我们假设抑郁症与语音状态轨迹的重复结构改变相关,反映发声系统随时间重访声学状态的方式变化。基于DAIC-WOZ数据集中142名有标注参与者,将帧级COVAREP轨迹建模为非线性动力系统,从74个语音通道中提取重复性生物标志物。采用带特征选择和分层交叉验证的逻辑回归评估分类性能。重复性生物标志物的平均交叉验证AUC达0.689,优于静态声学基线、熵动态特征、赫斯特指数特征、确定性特征及类李雅普诺夫不稳定性代理指标。置换检验显示统计显著性(p=0.004)。合并交叉验证预测结果得AUC 0.665,95% bootstrap置信区间为[0.568, 0.758]。结果表明,抑郁症可能表现为对话语音动态中重复结构的改变,支持非线性状态空间分析作为数字精神病生物标志物的有前景方向。
原文摘要 · Abstract (English)
Digital biomarkers for depression have largely relied on static acoustic descriptors, pooled summary statistics, or conventional machine learning representations. Such approaches may miss nonlinear temporal organization embedded in conversational vocal dynamics. We hypothesized that depression is associated with altered recurrence structure in vocal state trajectories, reflecting changes in how the vocal system revisits acoustic states over time. Using the depression subset of the DAIC-WOZ corpus with 142 labeled participants, we modeled frame-level COVAREP trajectories as nonlinear dynamical systems and derived recurrence-based biomarkers from 74 vocal channels. Logistic regression with feature selection and stratified cross-validation evaluated classification performance. Recurrence-based biomarkers achieved a mean cross-validated AUC of 0.689, exceeding static acoustic baselines, entropy-dynamics features, Hurst exponent features, determinism features, and Lyapunov-like instability proxies. Permutation testing indicated statistical significance with $p=0.004$. Pooled cross-validated predictions yielded AUC 0.665 with a 95\% bootstrap confidence interval of [0.568, 0.758]. These findings suggest that depression may be characterized by altered recurrence structure in conversational vocal dynamics and support nonlinear state-space analysis as a promising direction for digital psychiatric biomarkers.
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