用胎儿心律信号预测产妇高血压,实现低成本连续监测
Multi-View Hierarchical Representation Learning of Fetal Hemodynamics for Maternal Hypertension Detection at the Edge

- 构建分层注意力网络,融合多视角与原型对比学习
- 在8170次产检中达0.80的AUROC,边缘部署无性能下降
- 适合产科远程监测、低资源地区妊娠管理应用
妊娠期高血压疾病仍是全球孕产妇和胎儿患病的主要原因,但现有诊断依赖间断的袖带血压测量,易产生偏差且无法捕捉连续生理动态。越来越多证据表明,胎儿心血管活动与母体-胎盘血流动力学相关,可能蕴含产妇高血压的标志。为此,我们收集了来自危地马拉农村地区3,255名孕妇、8,170次产前检查的胎儿一维多普勒超声数据及对应母体血压。我们提出AutoHyPE,一种分层注意力网络,建模信号的短时与长时结构,结合新颖的原型对比学习与多视角策略,在长尾类别分布和生物变异性下提升表征鲁棒性。AutoHyPE在产妇高血压检测中达到0.80的AUROC,优于基线方法,且在边缘部署场景中无性能下降。研究发现,胎儿心脏机械活动包含反映产妇高血压状态的血流动力学特征。这支持了一种基于现有低成本超声技术的连续、客观孕产妇健康监测新范式,为传统血压测量提供互补方案,推动可扩展的产前护理。
原文摘要 · Abstract (English)
Hypertensive disorders of pregnancy remain a leading cause of maternal and fetal morbidity worldwide, yet diagnosis relies on intermittent cuff-based blood pressure measurements that are prone to bias and fail to capture continuous physiological dynamics. Growing evidence suggests that fetal cardiovascular activity is associated with maternal-placental hemodynamics and may encode markers of maternal hypertension. To analyze this, we collected a large-scale dataset of fetal one-dimensional Doppler ultrasound recordings paired with maternal blood pressure from 3,255 pregnant women across 8,170 antenatal visits in rural Guatemala. We developed AutoHyPE, a hierarchical attention network that models short- and long-term signal structure, incorporating a novel prototype-based contrastive learning and multi-view strategy to enhance representation robustness under long-tailed class distribution and biological variability. AutoHyPE achieved an AUROC of 0.80 for maternal hypertension detection, outperforming baseline approaches while maintaining balanced performance across classes, with no performance degradation in an edge deployment scenario. Our findings demonstrated that fetal cardiac mechanical activity contains hemodynamic features indicative of maternal hypertension status. This supports a promising paradigm shift toward continuous, objective monitoring of maternal health using existing, low-cost ultrasound technology and introduces a complementary approach to traditional methods based on blood pressure measurements, advancing scalable prenatal care.
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