arXiv:2605.03570cs.LGcs.AI2026-05中稿 · publication in EMB…

分离临床数据中的共用与任务特异性表征,提升多结果预测精度。

Disentangling Shared and Task-Specific Representations from Multi-Modal Clinical Data

论文配图:Disentangling Shared and Task-Specific Representations from Multi-Modal Clinical Data
图 1 · 摘自论文原文
  • 用正交分解将患者表征拆分为共用和任务特异两部分,保持几何正交性。
  • 在12,430名外科患者上,平均AUC达87.5%,平均AUPRC达37.2%。
  • 特别适合处理罕见事件的不平衡临床数据,对稀有病预测更有效。

真实世界临床数据具有多模态特性,能提供互补证据以支持多个相关结局的联合评估。尽管多任务学习可通过跨结局共享信息提升效率,但现有方法常难以平衡共用表征学习与任务特异性建模。硬参数共享在任务梯度冲突时可能引发负迁移,而灵活共享仍可能导致共用与任务特异性信号纠缠。为此,我们提出一种基于统一Transformer的多任务框架,引入正交任务分解(OrthTD),将患者表征分解为共用与任务特异性子空间,并施加几何正交约束以减少冗余、隔离任务特异性信号。我们在包含12,430名外科患者的现实队列上评估了OrthTD,用于预测四个临床结局。OrthTD实现平均AUC 87.5%、平均AUPRC 37.2%,显著优于先进表格与多任务方法。尤其在AUPRC上表现突出,表明其在不平衡临床数据中识别罕见事件的能力更强。结果表明,强制非冗余的共用与任务特异性表征可有效提升多结局预测性能。

原文摘要 · Abstract (English)

Real-world clinical data is inherently multimodal, providing complementary evidence that mirrors the practical necessity of jointly assessing multiple related outcomes. Although multi-task learning can improve efficiency by sharing information across outcomes, existing approaches often fail to balance shared representation learning with outcome-specific modeling. Hard parameter sharing can trigger negative transfer when task gradients conflict, while flexible sharing may still entangle shared and task-specific signals. To address this, we propose a multi-task framework built on a unified Transformer for multimodal fusion, augmented with Orthogonal Task Decomposition (OrthTD) to split patient representations into shared and task-specific subspaces and impose a geometric orthogonality constraint to reduce redundancy and isolate task-specific signals. We evaluated OrthTD on a real-world cohort of 12,430 surgical patients for predicting four outcomes. OrthTD achieved average AUC (area under the receiver operating characteristic curve) of 87.5% and average AUPRC (area under the precision-recall curve) of 37.2%, consistently outperformed advanced tabular and multi-task methods. Notably, OrthTD achieves substantial gains in AUPRC, indicating superior performance in identifying rare events within imbalanced clinical data. These results suggest that enforcing non-redundant shared and task-specific representations can improve multi-outcome prediction from multimodal clinical data.

多任务学习临床预测表征分离正交分解

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