arXiv:2605.07026q-bio.NCcs.AI2026-05

通过解耦多脑图谱功能连接,提升神经精神疾病表征的一致性。

Learning Cross-Atlas Consistent Brain Disorder Representations via Disentangled Multi-Atlas Functional Connectivity Learning

论文配图:Learning Cross-Atlas Consistent Brain Disorder Representations via Disentangled Multi-Atlas Functional Connectivity Learning
图 1 · 摘自论文原文
  • 多分支框架联合学习不同脑图谱的功能连接特征。
  • 在ADNI和ADHD-200数据集上表现优于单图谱与现有多图谱模型。
  • 适合研究跨图谱一致性、疾病表征的脑影像分析者使用。

基于静息态fMRI的功能连接(FC)广泛用于刻画神经与精神疾病中的大规模脑网络改变。然而,FC构建高度依赖脑图谱选择,不同分割方案可能强调不同组织特征,导致表征不一致。现有多图谱方法虽部分缓解此问题,但通常在较浅层融合特征或预测结果,而单图谱解耦方法未显式处理跨图谱异质性。本文提出多图谱解耦连接学习(MADCLE),一种多分支表示学习框架,联合编码来自不同脑图谱的FC矩阵。不同于引入单一共享隐变量,MADCLE学习各图谱的疾病相关表征,并通过分布对齐实现跨图谱一致性。同时,通过协变量相似性监督、图谱特定重建和去相关约束,分别建模协变量相关与图谱依赖的残差因子,减少非疾病及图谱依赖信息对疾病嵌入的干扰。在ADNI和ADHD-200数据集上的实验表明,MADCLE性能优于单图谱基线、多图谱GNN/Transformer模型及近期一致性框架,支持结构化解耦在异构分割方案下基于FC的疾病识别潜力。

原文摘要 · Abstract (English)

Functional connectivity (FC) derived from resting-state fMRI is widely used to characterize large-scale brain network alterations in neurological and psychiatric disorders. However, FC construction critically depends on the choice of brain atlas, and different parcellations may emphasize distinct organizational features, leading to heterogeneous and sometimes inconsistent representations. Existing multi-atlas approaches partially alleviate this issue but often fuse atlas-derived features or predictions at a relatively shallow level, while single-atlas disentanglement methods do not explicitly address cross-atlas heterogeneity. We propose Multi-Atlas Disentangled Connectivity LEarning (MADCLE), a multi-branch representation learning framework that jointly encodes FC matrices derived from different brain atlases. Rather than introducing a single explicitly shared latent variable across parcellations, MADCLE learns atlas-wise disease-related representations and encourages them to be cross-atlas consistent through distributional alignment. Meanwhile, covariate-related and atlas-dependent residual factors are modeled separately using covariate similarity supervision, atlas-specific reconstruction, and decorrelation constraints, thereby reducing the leakage of non-disease and parcellation-dependent information into the disease-related embeddings. Experiments on the ADNI and ADHD-200 datasets suggest that MADCLE achieves competitive or improved performance compared with single-atlas baselines, multi-atlas GNN/Transformer models, and recent multi-atlas consistency frameworks. These results support the potential value of structured disentanglement for FC-based disorder identification under heterogeneous parcellation schemes.

脑图谱功能连接解耦学习疾病识别

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