arXiv:2605.08109cs.LGcond-mat.mtrl-sci2026-05

用深度学习预测微流控中粒子升力,不依赖具体几何形状。

Geometry-free prediction of inertial lift forces in microfluidic devices using deep learning

论文配图:Geometry-free prediction of inertial lift forces in microfluidic devices using deep learning
图 1 · 摘自论文原文
  • 用新参数集训练神经网络,避开显式几何描述。
  • 在未见通道形状上表现优于传统模型,泛化能力更强。
  • 可直接接入仿真软件,适合微流控设计与优化场景。

惯性微流控器件(IMDs)为颗粒(或细胞)操控提供低成本、高通量的替代方案,但其模拟需准确预测粒子迁移及升力,且受多种通道几何影响。近年研究显示机器学习可显著加速数值模拟,但需为每种独特截面类型(如矩形、三角形)单独训练模型,将负担转移至训练环节。本文提出一种新型升力预测方法,完全不包含显式几何参数。通过新参数集训练神经网络,模型在训练集通道几何上表现与现有模型相当,但在未见过的通道几何上泛化能力显著提升。所开发的升力模型可轻松集成至粒子追踪仿真软件,能准确预测多种通道设计下的粒子迁移模式,与文献结果一致。

原文摘要 · Abstract (English)

Inertial microfluidic devices (IMDs) offer low-cost, high-throughput alternative techniques for many traditional particle- (or cell-) manipulation tasks, but simulating them requires being able to predict particle migration, and thus particle lift forces, under a variety of possible channel geometries. Recent work has demonstrated that machine learning models can be used to drastically speed up these numerical simulations, but doing so required training individual models for every unique channel cross-section type (e.g., rectangular, triangular) -- shifting the burden from the simulation step to the training step. In this paper, we develop a novel approach for predicting particle lift forces that contains no explicit geometric parameters. We train a neural network model using a new parameter set and show that while it performs comparably to existing models on channel geometries in the training set, it is able to generalize to unseen channel geometries far more effectively. We show that the lift force model developed herein can be easily transferred to particle tracing simulation software, where it is capable of predicting particle migration patterns consistent with the literature across a variety of channel designs.

微流控深度学习升力预测

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