用多个智能体自动完成脑成像分析,像人一样思考并优化流程。
Towards a Virtual Neuroscientist: Autonomous Neuroimaging Analysis via Multi-Agent Collaboration

- 多智能体协作生成可执行代码,动态调整分析流程。
- 在ADHD-200和ADNI数据集上预测性能优于传统方法。
- 适合需要自动化、可解释性脑成像分析的研究者。
将神经影像数据转化为临床可用生物标志物是一个知识密集且耗时的过程。尽管fMRIPrep等标准化工作流提升了稳健性和效率,但它们配置固定,无法根据下游目标推理、权衡策略或实现中间证据与后续决策的闭环反馈,导致专家陷入手动试错调参和修复流程失败的循环,严重制约了临床生物标志物开发的可扩展性。为此,我们提出NEXUS,一个将神经影像工作流执行与科学目标理解相结合的自主多智能体框架。不同于传统的扁平工具调用代理,NEXUS采用以代码为中心的执行范式,使专业智能体通过组合领域特定原语协作合成与优化可执行程序,实现对运行时观测的动态适应。此外,我们设计了分层验证框架,结合队列级指标筛查与智能体视觉检查,驱动基于证据的工作流修复。在ADHD-200和ADNI数据集上的实验表明,NEXUS不仅在预测性能上超越标准工作流基线,还展现出策略探索和自适应优化等复杂智能体行为。代码已开源:https://github.com/LearningKeqi/Virtual-Neuroscientist-NEXUS。
原文摘要 · Abstract (English)
Transforming neuroimaging data into clinically actionable biomarkers is a knowledge-intensive and labor-intensive process. Standardized workflows such as fMRIPrep have improved robustness and efficiency, but they are statically configured and cannot reason about downstream objectives, deliberate over alternative strategies, or close the loop between intermediate evidence and subsequent decisions in the way a human researcher would. This lack of closed-loop adaptation often leaves domain experts trapped in a cycle of manual trial-and-error to tune parameters and remediate pipeline failures, severely constraining the scalability of clinical biomarker development. To bridge this gap, we introduce NEXUS, an autonomous multi-agent framework that integrates neuroimaging workflow execution with scientific-objective understanding. Unlike conventional flat toolcalling agents, NEXUS adopts a code-centric execution paradigm where specialist agents collaboratively synthesize and optimize executable programs over composable domain-specific primitives. This design enables robust, long-horizon workflow construction that adapts dynamically to runtime observations. Furthermore, we propose a hierarchical verification framework for autonomous quality control, integrating cohort-level metric screening with agentic visual inspection to drive evidence-grounded workflow remediation. Experiments on ADHD-200 and ADNI demonstrate that NEXUS outperforms standard workflow-based baselines in predictive performance while exhibiting sophisticated agentic behaviors, including strategy exploration and adaptive refinement. The code is available at https://github.com/LearningKeqi/Virtual-Neuroscientist-NEXUS.
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