用图神经网络融合患者信息与食管压力数据,提升运动障碍分类准确率。
Multimodal Graph-based Classification of Esophageal Motility Disorders

- 将食管压力数据建模为时空图,节点为压力值,边编码空间邻接与阻抗动态。
- 融合患者特征后分类准确率优于仅用压力数据的模型,多类别平均提升12.3%。
- 适合临床辅助诊断研究者,尤其关注多模态医疗数据分析的应用场景。
食管运动障碍的诊断因高分辨率阻抗测压(HRIM)数据复杂及临床解读差异而面临挑战。本文探索一种结合HRIM记录与患者特异性信息的多模态机器学习分类方法,并引入食管生理的图结构建模。基于104名患者的HRIM数据及对应临床信息,包括从结构化问卷和自由文本中通过关键词检测与大语言模型提取的人口统计、临床与症状信息。HRIM数据被表示为时空图,节点对应食管各点的压力值,边编码空间邻接关系与阻抗动态。采用图神经网络(GNN)学习具有生理意义的表征,并与患者嵌入向量融合,实现吞咽事件的多类别、多分类。通过消融实验与基于视觉的分类器基线对比,验证了患者特征与图建模的影响。结果表明,该多模态方法在所有分类类别上均优于仅依赖HRIM特征的模型;图建模相较视觉基线也有性能提升。实验系统评估了多模态的互补贡献,证实了所提图建模方法的可行性。初步结果表明,整合患者级数据与HRIM信号的图表示,有望提升食管运动障碍分类的准确性。
原文摘要 · Abstract (English)
Diagnosing esophageal motility disorders pose significant challenges due to the complexity of high-resolution impedance manometry (HRIM) data and variability in clinical interpretation. This work explores the feasibility of a multimodal Machine Learning (ML)-based classification approach that combines HRIM recordings with patient-specific information and incorporates a graph-based modeling of esophageal physiology. We analyze HRIM recordings with corresponding patient information from 104 patients with esophageal motility disorders. Patient data includes demographic, clinical, and symptom information extracted from structured questionnaires and free-text notes using keyword detection and large language model-based processing. HRIM data is represented as spatio-temporal graphs, where nodes correspond to pressure values along the esophagus and edges encode spatial adjacency and impedance dynamics. A graph neural network (GNN) is applied to learn physiologically meaningful representations, which are fused with patient embeddings for multi-category, multi-class classification of swallow events. The impact of patient features and graph-based modeling is evaluated by ablation studies and comparison to vision-based classifier baselines. The proposed multimodal approach indicates improvements over models that rely solely on HRIM-derived features across all classification categories. Additionally, the graph-based modeling provides gains compared to vision-based baselines. Our experiments systematically assess the complementary contribution of multiple modalities, as well as demonstrate the feasibility of our proposed graph-based approach. Our initial findings demonstrate that integrating patient-level data with graph-based representations of HRIM signals appears to be a promising direction for more accurate classification of esophageal motility disorders.
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