通过拓扑与几何特征增强睡眠嵌入,提升儿童睡眠分析的可解释性与准确性。
Uncovering Trajectory and Topological Signatures in Multimodal Pediatric Sleep Embeddings

- 用PHATE坐标和持久同调分析嵌入序列的几何拓扑结构
- 融合临床数据后,四种事件预测的AUPRC最高提升至0.48
- 适合关注可解释性与极端不平衡场景的睡眠研究者
尽管生成模型在儿童睡眠分析中展现出潜力,但其多模态嵌入的潜在结构仍不清晰。本文研究了由多模态掩码自编码器嵌入的30秒儿童多导睡眠图(PSG)片段序列中的全夜诊断信息。通过引入PHATE生成的每片段坐标、整夜运动描述符、嵌入点云的持久同调摘要及电子健康记录(EHR),检验其是否带来任务相关信号。选用线性与MLP模型以保证可解释性而非追求最优性能,结果表明几何、拓扑与临床特征均提供互补增益。对于二分类任务,特征重要性因任务而异,更表达性的后期融合模型普遍表现更优:脱氧饱和度预测的AUPRC从0.26升至0.34,脑电觉醒从0.31升至0.48,低通气从0.09升至0.22,呼吸暂停从0.05升至0.14。同时报告了布里尔分数与期望校准误差,全融合模型在所有四项任务中均实现最佳校准。研究揭示,潜在几何/拓扑结构与EHR可提供超越嵌入本身的互补、可解释信号,提升校准性与极端不平衡下的鲁棒性。
原文摘要 · Abstract (English)
While generative models have shown promise in pediatric sleep analysis, the latent structure of their multimodal embeddings remains poorly understood. This work investigates session-wide diagnostic information contained in the sequences of 30-second pediatric PSG epochs embedded by a multimodal masked autoencoder. We test whether augmenting embeddings with PHATE-derived per-epoch coordinates and whole-night movement descriptors, persistent homology summaries of the embedding cloud, and EHR yields task-relevant signals. Simple linear and MLP models, chosen for interpretability rather than state-of-the-art performance, show that geometric, topological, and clinical features each provide complementary gains. For binary predictions, feature importance is task-dependent, and more expressive late-fusion models generally perform better, with AUPRC improving from 0.26 to 0.34 for desaturation, 0.31 to 0.48 for EEG arousal, 0.09 to 0.22 for hypopnea, and 0.05 to 0.14 for apnea. We also report Brier score and Expected Calibration Error, where the full fusion model yields the best calibration across all four binary tasks. Our study reveals that latent geometry/topology and EHR offer complementary, interpretable signals beyond embeddings, improving calibration and robustness under extreme imbalance.
Thank you to arXiv for use of its open access interoperability. PaperDance 不是 arXiv 官方产品;中文卡片由大模型生成,请以原文为准。