arXiv:2605.14883eess.SPcs.HC2026-05中稿 · IEEE SMC 2026被引 1

用脑电+AR眼动测试,精准测出轻度脑损伤患者的眼球反应时间。

BCI-Based Assessment of Ocular Response Time Using Dynamic Time Warping Leveraging an RDWT-Driven Deep Neural Framework

论文配图:BCI-Based Assessment of Ocular Response Time Using Dynamic Time Warping Leveraging an RDWT-Driven Deep Neural Framework
图 1 · 摘自论文原文
  • 用冗余小波变换提取脑电信号特征,再通过深度网络建模
  • 动态时间对齐分析显示追踪任务反应时间差异显著
  • 适合做脑损伤早期筛查的便携式多模态评估系统

轻度创伤性脑损伤(mTBI)在早期难以诊断。眼动功能障碍是其明确标志,推动了可穿戴设备捕捉眼动行为与神经生理信号的需求。本文提出一个初步框架,将脑电图(EEG)与基于增强现实(AR)的眼动/前庭筛查(VOMS)任务结合,估算个体化眼球反应时间。经带通滤波与平均参考预处理后的脑电信号,通过冗余离散小波变换(RDWT)驱动的深度神经网络进行分析。小波系数经可训练零相位卷积滤波后,通过逆RDWT重构至时域,再使用2D卷积层与卷积LSTM进行通道间时空过滤与解码。消融实验证明小波域滤波有效降噪并提升预测性能。滑动窗口预测经皮尔逊相关性验证(>0.5),随后采用动态时间对齐(DTW)估计眼球反应时间。DTW指标揭示受试者在不同任务中的反应时间存在差异,曼-惠特尼检验支持该发现。交叉相关分析显示:追踪任务呈反应性跟踪,扫视任务则具前瞻响应。总体表明,追踪任务最能区分反应时间差异,且基于RDWT的脑电特征与DTW度量结合,为多模态mTBI评估提供了潜力。

原文摘要 · Abstract (English)

Mild traumatic brain injury (mTBI) is a prevalent condition that remains difficult to diagnose in its early stages. Oculomotor dysfunction is a well-established marker of mTBI, motivating the development of portable tools that capture both eye-movement behavior and underlying neurophysiology. In this work, we present an initial framework that integrates electroencephalogram (EEG) with augmented-reality (AR)-based Vestibular/Ocular Motor Screening (VOMS) tasks to estimate subject-specific ocular response times. Pre-processed EEG signals, obtained through band-pass filtering and average referencing, are analyzed using a Redundant Discrete Wavelet Transform (RDWT)-driven deep neural framework. The RDWT coefficients are subjected to trainable zero-phase convolutional filtering and reconstructed into the time domain via inverse RDWT, followed by channel-wise temporal and spatial filtering using 2D convolution layers and convolutional-LSTM-based decoding. An ablation study demonstrates that wavelet-domain filtering serves as an effective denoising strategy, improving prediction performance. Sliding-window predictions were validated using Pearson correlation (> 0.5), and Dynamic Time Warping (DTW) was subsequently used to estimate ocular response times. DTW-derived metrics revealed VOM-task-dependent differences in ocular response time between participants, characterized using Mann-Whitney U tests. Cross-correlation analysis further revealed task-dependent temporal behaviors: pursuit tasks exhibited reactive tracking, whereas saccades showed anticipatory responses. Overall, the results highlight pursuit tasks as particularly informative for distinguishing timing differences and demonstrate the potential of RDWT-based EEG features combined with DTW metrics for multimodal mTBI assessment.

脑损伤眼动检测脑电信号多模态

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