用概率链式思维补全技术,提升医疗记录长期推理准确性
COTCAgent: Preventive Consultation via Probabilistic Chain-of-Thought Completion

- 分层架构融合统计计算与语言推理,避免医学趋势幻觉
- 在自建数据集上达90.47%准确率,健康基准测试超70%
- 适合需要严谨长时医疗分析的临床决策场景
随着大语言模型在医疗领域的应用,智能临床决策支持快速发展。纵向电子健康记录(EHR)为精准诊断提供重要时间证据,但现有大模型在处理长时序EHR时存在严重缺陷:一是缺乏细粒度统计推理能力,常在文本隐含定量信息时产生临床趋势幻觉,影响诊断判断;二是长时序数据非均匀采样与标签稀缺,导致模型难以捕捉远距离时间依赖,限制可靠推理。为此,本文提出概率链式思维补全代理(COTCAgent),一种用于纵向电子健康记录的分层推理框架。包含三个核心模块:时间-统计适配器(TSA)将分析计划转化为可执行代码以生成标准化趋势;链式思维补全(COTC)层结合症状-趋势-疾病知识库加权评分评估疾病风险;有界补全模块通过标准化询问与迭代评分约束获取结构化证据,确保推理严密性。该框架解耦统计计算、特征匹配与语言生成,不依赖复杂多模态输入,实现高效低开销的长时序记录分析。实验表明,基于Baichuan-M2的COTCAgent在自建数据集上达到90.47% Top-1准确率,在HealthBench上达70.41%,优于现有医疗代理与主流大模型。代码已开源。
原文摘要 · Abstract (English)
As large language models empower healthcare, intelligent clinical decision support has developed rapidly. Longitudinal electronic health records (EHR) provide essential temporal evidence for accurate clinical diagnosis and analysis. However, current large language models have critical flaws in longitudinal EHR reasoning. First, lacking fine-grained statistical reasoning, they often hallucinate clinical trends and metrics when quantitative evidence is textually implied, biasing diagnostic inference. Second, non-uniform time series and scarce labels in longitudinal EHR hinder models from capturing long-range temporal dependencies, limiting reliable clinical reasoning. To address the above limitations, this work presents the Probabilistic Chain-of-Thought Completion Agent (COTCAgent), a hierarchical reasoning framework for longitudinal electronic health records. It consists of three core modules. The Temporal-Statistics Adapter (TSA) converts analytical plans into executable code for standardized trend output. The Chain-of-Thought Completion (COTC) layer leverages a symptom-trend-disease knowledge base with weighted scoring to evaluate disease risk, while the bounded completion module acquires structured evidence through standardized inquiries and iterative scoring constraints to ensure rigorous reasoning. By decoupling statistical computation, feature matching, and language generation, the framework eliminates reliance on complex multi-modal inputs and enables efficient longitudinal record analysis with lower computational overhead. Experimental results show that COTCAgent powered by Baichuan-M2 achieves 90.47% Top-1 accuracy on the self-built dataset and 70.41% on HealthBench, outperforming existing medical agents and mainstream large language models. The code is available at https://github.com/FrankDengAI/COTCAgent/.
Thank you to arXiv for use of its open access interoperability. PaperDance 不是 arXiv 官方产品;中文卡片由大模型生成,请以原文为准。