用头皮脑电重建颅内信号,无需为每个病人单独训练模型。
Cross-Subject Intracranial EEG Reconstruction from Scalp Recordings Using Multi-Scale Cross-Attention Transformers

- 通过两阶段迁移学习,从头皮脑电预测跨被试颅内信号。
- 在运动皮层区域相关性最高达r=0.864,平均相关性r=0.545。
- 仅需几分钟校准即可适配新患者,适合临床与脑机接口应用。
颅内脑电(iEEG)提供高保真神经信号,对临床和脑机接口至关重要,但采集需侵入性手术。以往研究多依赖个体特异性模型,导致训练数据获取仍需手术,实用性受限。本文提出CAST(Cross-Attention Spatial-Temporal Transformer),通过两阶段迁移学习策略,从头皮脑电重建跨被试的多通道颅内信号。首先,时间编码器在三个分辨率下提取多尺度神经表征;其次,因电极位置差异大,使用目标被试少量数据(几分钟)校准通道感知解码器。在包含1,282个iEEG通道的两个公开数据集上,采用留一被试交叉验证。结果表明,该方法对靠近头皮表面的皮层信号重建效果显著优于深部皮层活动;在明显可观察的感觉运动区,预中央回最高相关性达r=0.864。结合通道选择策略,对可用被试的平均相关性达到r=0.545,优于以往同被试基线模型。结果表明,仅需简短校准,即可实现未见过被试的皮层iEEG信号重建,无需大量个体化训练。
原文摘要 · Abstract (English)
Intracranial EEG (iEEG) provides high-fidelity neural recordings essential for clinical and brain-computer interface applications, but acquiring these signals requires invasive surgery. While recent studies have attempted to estimate iEEG from non-invasive scalp EEG, most rely on patient-specific models, creating a circular dependency: if surgery is required to collect training data, the non-invasive model offers limited practical benefit. In this study, we address the challenge of cross-subject iEEG reconstruction by predicting intracranial signals for unseen patients using models trained on other individuals. We propose CAST (Cross-Attention Spatial-Temporal Transformer), a machine learning framework that translates scalp EEG into multi-channel iEEG waveforms through a two-stage transfer learning strategy. First, a temporal encoder extracts multi-scale neural representations at three different resolutions. Then, because electrode placements vary substantially across patients, a channel-aware decoder is calibrated using only a few minutes of data from the target subject. We evaluated the proposed method using leave-one-subject-out cross-validation on two public datasets comprising 1,282 iEEG channels. Experimental results demonstrate that CAST reconstructs cortical signals located near the scalp surface substantially better than deep subcortical activity. In highly observable sensorimotor regions, the model achieved peak correlations of up to r=0.864 in the precentral gyrus. Furthermore, with a channel selection strategy, CAST obtained a mean correlation of r=0.545 on viable subjects, outperforming previous within-subject baselines. These findings indicate that cortical iEEG signals can be reconstructed for unseen subjects from scalp EEG without extensive patient-specific training, and that only a brief calibration phase is sufficient to adapt the model to new hardware configurations.
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