基于单帧心电图生成完整心动周期的精准心脏运动,适配不同病变特征。
RePCM: Region-Specific and Phenotype-Adaptive Bi-Ventricular Cardiac Motion Synthesis

- 分区域学习运动特征,构建数据驱动的功能分区结构。
- 在三组疾病数据上,几何与功能指标均显著提升。
- 针对不同病变类型自适应建模,适合心脏病研究与临床分析。
心脏在一个心动周期中的运动对量化局部功能至关重要,且受心血管疾病显著影响。由于难以获取时间密集的网格序列,本文聚焦于利用更易获得的舒张末期(end-diastolic, ED)帧推断完整周期的运动序列。由于存在强烈的区域差异和疾病特异性,传统方法常因依赖全局模式优化的生成模型而过度平滑。为此,我们提出区域感知且表型自适应的双心室心脏运动合成方法(RePCM),用于单帧双心室网格运动补全。第一阶段通过重建网络学习顶点级运动描述符,聚类生成数据驱动的功能分区,提供显式的运动衍生区域结构。第二阶段引入区域特定注入模块,在条件变分自编码器中强制掩码化、同步的区域间交换,保留局部动态特性并限制跨区域混杂。同时,基于ED形态的表型自适应专家混合先验,利用解剖引导线索建模潜在运动趋势,并捕捉疾病间的差异性。在三个涵盖不同心血管疾病的公开数据集上的实验表明,该方法在几何与功能度量上均取得一致提升,且更有效地保持了区域特异性动态。
原文摘要 · Abstract (English)
Cardiac motion over a cardiac cycle is crucial for quantifying regional function and is strongly affected by cardiovascular diseases. Since temporally dense mesh sequences are difficult to obtain in practice, we focus on leveraging the more accessible end-diastolic frame to infer a full-cycle sequence. Due to strong regional and disease-specific differences, traditional methods often oversmooth the data by relying on generative models that are optimized for global patterns. To address this problem, we propose Region-Aware and Phenotype-Adaptive Bi-Ventricular Cardiac Motion Synthesis (RePCM) for single frame Bi-ventricular mesh motion completion. In Stage I, a reconstruction network learns vertex wise motion descriptors and clustering yields a data driven functional partition, providing an explicit motion derived region structure. In Stage II, a Region-Specific Injection Module enforces masked, synchronized region exchange within a conditional VAE, preserving localized specific dynamics and restricting cross-region mixing. A Phenotype-Adaptive Mixture-of-Experts prior conditioned on ED shape uses anatomy-guided cues to model latent motion trends and capture inter-disease variability. Experiments on three datasets covering different cardiovascular diseases show consistent gains in geometric and functional metrics and improved preservation of region specific dynamics.
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