arXiv:2605.22968q-bio.QMcs.LG2026-05

用贝叶斯神经网络提升心电图筛查心脏病的可靠性,自动识别高风险病例。

Uncertainty-aware classification and triage of structural heart disease using electrocardiography and echocardiography metrics

论文配图:Uncertainty-aware classification and triage of structural heart disease using electrocardiography and echocardiography metrics
图 1 · 摘自论文原文
  • 采用贝叶斯神经网络结合心电图与超声心动图数据进行分类
  • 贝叶斯方法在不确定性量化上优于传统方法,准确率相当
  • 可作为分诊工具,优先处理高风险或结果不确定的患者

机器学习为通过非侵入性、易获取的检测手段筛查心血管疾病提供了方法创新。近年来,利用心电图(ECG)筛查结构性心脏病(SHD)成为热点,因其成本低、可及性强。这催生了EchoNext数据集——一个配对的ECG-超声心动图数据仓库,用于测试新型SHD检测方法。然而,较少研究探讨基于贝叶斯推断的概率化分类如何改善该场景下的不确定性量化。同时,也少有研究关注如何构建分诊系统以缓解医疗瓶颈,例如由专家超声技师远程审阅偏远地区诊所的数据。本研究利用现有ECG-超声心动图数据,对比了频率学与贝叶斯神经网络分类器。结果表明,贝叶斯方法在SHD分类性能上与频率学方法相当甚至更优,且具备更稳健的不确定性量化能力。我们展示了该不确定性感知分类方案在筛查中的应用实例,为机器学习助力临床分诊提供了概念验证,即当患者患病可能性高或测量结果不确定性大时,可优先分配给专家进一步评估。

原文摘要 · Abstract (English)

Machine learning methods provide a methodological innovation that can help screen for cardiovascular disease through noninvasive and readily available measurement modalities. Recent investments in using electrocardiogram (ECG) data to screen for structural heart disease (SHD) are one example, where ECGs provide a low-cost, available modality for screening. This has led to the EchoNext dataset, a paired ECG-echocardiogram data repository for testing new methods of SHD detection. However, relatively few studies have investigated how more probabilistic classification through Bayesian inference may improve uncertainty quantification in this setting. Moreover, few studies have considered how triage systems can be developed to alleviate healthcare bottlenecks, such as the review of data from underserved, rural clinics by expert sonographers for SHD assessment. In this study, we leverage existing ECG-echocardiogram data to compare frequentist and Bayesian neural network classifiers. We show that the Bayesian approach is comparable or better than frequentist methods in SHD classification, and that they have a more robust uncertainty quantification attached to them. We provide an example of how this uncertainty-aware classification scheme can be used for screening SHD, providing a proof-of-concept for how machine learning can help with triage in getting individuals expert sonographer input when SHD is highly likely or measurements are highly uncertain.

心脏病筛查贝叶斯神经网络医疗分诊多模态学习

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