用量子神经网络提升血细胞分类准确率,尤其在数据少、难度高的场景下表现更好。
Enhancing Blood Cells Classification using Hybrid Quantum Neural Networks

- 将经典ResNet与量子电路结合,通过量子变换增强特征表示。
- 在血细胞数据集上,宏F1分数最高提升3.7%,8类任务达98.69%准确率。
- 模型在真实量子硬件上仍稳定,适合医疗图像中复杂分类任务。
显微血细胞的精确分类仍是医学图像分析中的关键挑战,细微差异和数据有限常使传统深度学习模型受限。本文探索混合量子-经典神经网络(HQNN)在该领域的潜力,提出一种模块化架构:以预训练的ResNet-50为骨干网络,搭配低维潜在瓶颈和变分量子电路,可直接对比量子与纯经典变换机制。为隔离量子成分贡献,评估三种模型:HQNN、具有相似容量非线性层的纯经典对照模型、无中间变换的基线模型。在公开血细胞数据集Blood Cell Images和PBC上实验表明,HQNN在各评价指标上均表现更优或更均衡。在Blood Cell Images数据集上,宏F1分数相较经典基线最高提升3.7%;在更具挑战性的8类场景中,F1分数从98.54%提升至98.69%。在IBM量子硬件上的额外测试显示,模型对噪声具备鲁棒性,性能下降微小。结果表明,量子特征变换能增强判别性表征,尤其在高难度分类任务中,凸显了HQNN在医学影像中的实际应用潜力。
原文摘要 · Abstract (English)
Accurate classification of microscopic blood cells is still a critical task in medical image analysis, where subtle variations and limited data can challenge conventional deep learning models. As such, we investigate in this work the potential of Hybrid Quantum-Classical Neural Networks (HQNNs) to enhance feature representation and improve classification performance in this domain. We propose a modular architecture combining a pre-trained ResNet-50 backbone with a low-dimensional latent bottleneck and a variational quantum circuit, enabling a direct comparison between quantum-enhanced and purely classical transformation mechanisms. To isolate the contribution of the quantum component, we evaluate three architectures: a HQNN model, a Classical Matched Model with an additional nonlinear transformation layer of comparable capacity, and a baseline model without an intermediate transformation stage. Experiments conducted on two publicly available blood cell datasets, namely the Blood Cell Images dataset and the PBC dataset, demonstrate that HQNNs consistently achieve superior or more balanced performance across evaluation metrics. In the Blood Cell Images Dataset, the proposed approach improves macro F1-score by up to 3.7% compared to classical baselines, while improving the F1-score from 98.54% to 98.69% in the more challenging 8-class scenario with near-saturated performance. Additional evaluation on IBM quantum hardware shows that the model remains robust under noise, with only a modest performance degradation relative to simulated results. These results indicate that quantum feature transformations can enhance discriminative representations, particularly in challenging classification scenarios, and highlight the practical potential of HQNN models for medical imaging tasks.
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