融合胸部X光与电子病历,提升重症患者呼吸衰竭预测精度
Prospective evaluation of multimodal respiratory failure prediction: Do chest X-rays improve performance beyond EHR signals?

- 用门控机制动态融合电子病历与胸部X光特征,按需调用影像信息
- 24小时内预测插管风险的准确率(AUROC)达0.860,显著优于仅用病历的模型
- 对临床医生预测有明显提升,尤其在提高敏感度方面,适合重症监护场景
早期预测呼吸衰竭对重症监护室及时干预至关重要。现有基于电子健康记录(EHR)的模型可连续监测生理恶化,但可能无法充分捕捉胸片(CXR)反映的肺部病理生理变化。本研究探讨在仅使用EHR信号的基础上,加入胸片信息是否能提升对侵入性机械通气的前瞻性预测能力。我们构建了一个门控多模态框架,整合结构化EHR时序数据与基于基础模型的胸片表征。门控模块根据患者具体临床情境自适应控制影像特征的贡献,使模型在影像信息有信息量时优先依赖。我们在重症患者中前瞻性评估该框架在24小时内预测侵入性机械通气的能力,并与已有的仅用EHR的模型(Ventio)、临床医生在相同时间点的判断以及其它多模态变体进行比较。门控多模态模型的表现优于仅用EHR的基线,使用REMEDIS和MedInsight胸片表征时的AUROC分别为0.860和0.858,而Ventio为0.752。相较于医生预测,多模态框架显著提升了敏感度,同时保持良好特异度。相比仅用EHR的模型,多模态融合提升了特异度和阳性预测值,表明胸片信息可在特定患者中优化风险评估。结果支持自适应多模态融合作为将影像纳入前瞻性呼吸衰竭预测的实际策略。
原文摘要 · Abstract (English)
Early prediction of respiratory failure is critical for timely clinical intervention in intensive care units. Existing electronic health record (EHR)-based models can continuously monitor physiologic deterioration, but they may not fully capture pulmonary pathophysiology reflected in chest radiographs (CXRs). In this study, we ask whether CXR information improves prospective prediction of invasive mechanical ventilation beyond EHR signals alone. We develop a gated multimodal framework that integrates structured EHR time-series data with CXR foundation-model representations. The gating module adaptively controls the contribution of imaging features based on patient-specific clinical context, allowing the model to selectively rely on imaging information when it is informative. We prospectively evaluate the framework for predicting invasive mechanical ventilation within 24 hours in ICU patients and compare it with an established EHR-only model (Ventio), physician predictions obtained at matched clinical time points, and alternative multimodal variants. The gated multimodal models achieved higher discrimination than the EHR-only baseline, with AUROC values of 0.860 and 0.858 using REMEDIS and MedInsight CXR representations, respectively, compared with 0.752 for Ventio. Relative to physician predictions, the multimodal framework substantially improved sensitivity while maintaining favorable specificity. Compared with the EHR-only model, multimodal integration increased specificity and positive predictive value, suggesting that CXR information can refine risk estimation in selected patients. These findings support adaptive multimodal fusion as a practical strategy for incorporating imaging into prospective respiratory failure prediction.
Thank you to arXiv for use of its open access interoperability. PaperDance 不是 arXiv 官方产品;中文卡片由大模型生成,请以原文为准。